T淋巴细胞亚群及炎症指标对支原体肺炎患儿病情的评估价值  

Value of T-lymphocyte subsets and inflammatory indicators in assessing the condition of children with mycoplasma pneumoniae pneumonia

作　　者：姜帅 刘刚 姚虹 JIANG Shuai;LIU Gang;YAO Hong(Department of Clinical Laboratory,Xuzhou Children’s Hospital,Jiangsu,Xuzhou 221006,China;Department of Neonatology,Xuzhou Children’s Hospital,Jiangsu,Xuzhou 221006,China)

机构地区：[1]江苏省徐州市儿童医院检验科,江苏徐州221006 [2]江苏省徐州市儿童医院新生儿内科,江苏徐州221006

出　　处：《中国医药科学》2024年第23期189-193,共5页China Medicine And Pharmacy

基　　金：江苏省徐州市卫生健康委员会科技项目(XWKYHT20220087)。

摘　　要：目的探究T淋巴细胞亚群及炎症指标对支原体肺炎患儿病情的评估价值。方法选择2022年12月至2023年12月徐州市儿童医院收治的支原体肺炎患儿120例,依据英国胸科协会改良肺炎(CURB-65)评分将患儿分为轻症肺炎组(73例)和重症肺炎组(47例)。比较两组患儿炎症指标超敏C-反应蛋白(hs-CRP)、降钙素原(PCT)水平和T淋巴细胞亚群(CD3^(+)、CD4^(+)、CD8^(+)及CD4^(+)/CD8^(+))表达情况,分析CURB-65评分与T淋巴细胞亚群及炎症指标的相关性,并绘制受试者操作特征曲线(ROC)观察T淋巴细胞亚群联合炎症指标评估支原体肺炎患儿病情的价值。结果与轻症肺炎组比较,重症肺炎组患儿CD3^(+)、CD4^(+)及CD4^(+)/CD8^(+)水平均更低,hs-CRP、PCT、CD8^(+)水平更高;CURB-65评分与hs-CRP、PCT、CD8^(+)均呈正相关,与CD3^(+)、CD4^(+)呈负相关;联合预测的AUC为0.916(95%CI:0.850~0.981),灵敏度为90.82%,特异度为83.21%。结论T淋巴细胞亚群及炎症指标对支原体肺炎患儿病情的评估有较高的特异度和灵敏度,具有临床诊断价值。Objective To investigate the value of T-lymphocyte subsets and inflammatory indicators in assessing the condition of children with mycoplasma pneumoniae pneumonia.Methods A total of 120 children with mycoplasma pneumoniae pneumonia admitted to Xuzhou Children’s Hospital from December 2022 to December 2023 were selected.They were divided into the mild pneumonia group(73 patients)and the severe pneumonia group(47 patients)based on the confusion,uremia,respiratory,blood pressure,age≥65 years(CURB-65)score.Inflammatory indicators including hypersensitive C-reactive protein(hs-CRP)and proealcitonin(PCT)level,and the expression of T-lymphocyte subsets(CD3^(+),CD4^(+),CD8^(+),and CD4^(+)/CD8^(+))were compared between the two groups of children.The correlation of the CURB-65 score with T-lymphocyte subsets and inflammatory indicators was analyzed.The receiver operating characteristic curves were plotted to observe the value of T-lymphocyte subsets combined with inflammatory indicators in assessing the condition of children with mycoplasma pneumoniae pneumonia.Results CD3^(+),CD4^(+)and CD4^(+)/CD8^(+)levels were lower,and hs-CRP,PCT,and CD8^(+)levels were higher in children of the severe pneumonia group than those of the mild pneumonia group.The CURB-65 score was positively correlated with hs-CRP,PCT,and CD8^(+),and negatively correlated with CD3^(+)and CD4^(+).The joint predictive AUC was 0.916(95%CI:0.850-0.981),with a sensitivity of 90.82%and a specificity of 83.21%.Conclusion T-lymphocyte subsets and inflammatory indicators show high specificity and sensitivity in assessing the condition of children with mycoplasma pneumoniae pneumonia,and have the clinical diagnostic value.

关 键 词：支原体肺炎 T淋巴细胞亚群 炎症指标 CURB-65评分 

分 类 号：R725.6[医药卫生—儿科]