夏日户外时间与近视的因果关系:基于孟德尔随机化研究  

The causal relationship between time spent outdoors in summer and myopia:based on Mendelian randomization

作　　者：黄莉红 张大铮[1,3] 刘敏 HUANG Lihong;ZHANG Dazheng;LIU Ming(Dujiangyan Medical Centre,Chengdu 611830,Sichuan Province,China;Chengdu University of Traditional Chinese Medicine,Chengdu 610075,Sichuan Province,China;Dujiangyan Juvenile Myopia Prevention and Treatment Center,Chengdu 611843,Sichuan Province,China;Chengdu Women’s and Children’s Medical Center,Chengdu 610073,Sichuan Province,China)

机构地区：[1]都江堰市医疗中心,四川省成都市611830 [2]成都中医药大学,四川省成都市610075 [3]都江堰市青少年近视防治中心 [4]成都市妇女儿童医学中心,四川省成都市610073

出　　处：《眼科新进展》2025年第1期50-54,共5页Recent Advances in Ophthalmology

摘　　要：目的采用两样本孟德尔随机化方法(MR)研究夏日户外时间对于近视的因果关系。方法本研究进行了两样本孟德尔随机化分析,对全基因组关联研究(GWAS)的汇总数据进行分析,以确定夏日户外时间是否对近视产生因果影响。暴露事件和结局事件的汇总数据仅来自欧洲裔,以全基因组显著(P<0.5×10^(-8))和独立(r 2<0.001)单核苷酸多态性(SNP)作为工具变量,本次夏日户外时间的数据共包含419314例样本,近视数据共包含367906例样本。以OR值评价夏日户外时间对近视风险的因果关系。同时分析了异质性和敏感性的效果估计的稳健性和多效性。结果使用33个SNP进行分析后,随机效应逆方差加权IVW结果:OR=0.6049522,95%CI为0.527~0.693,P=4.959237×10^(-13),研究发现,夏日户外时间和近视有负向因果关系,同时,在效果估计中具有一定的异质性(I^(2)=0.42)及没有发现显著多效性(截距=-0.0066,SE=0.00482,P=0.182)。IVW分析结果显示,夏日户外时间缩短可以增加患近视的风险。同时,使用加权中值法(WM)和MR-Egger回归法分析也表现出相似的结果。敏感性分析结果显示,遗传多效性不会对结果产生偏倚。综上所述,对数变换后的夏日户外时间每降低一个标准差,会导致近视的风险增加39%。结论夏日户外时间对近视的发生可能存在负向因果关系。Objective To study the causal relationship between time spent outdoors in summer and myopia by using a two-sample Mendel randomization analysis.Methods In this study,a two-sample Mendelian randomization(MR)analysis was conducted,and the data from the Genome-Wide Association Studies(GWAS)were analyzed to identify whether time spent outdoors in summer could exert a causal effect on myopia.The data of exposure events and outcome events were collected based on European descent,with the significant whole genome(P<0.5×10^(-8))and independent(r 2<0.001)single nucleotide polymorphism(SNP)as instrumental variables.The data on time spent outdoors in summer included 419314 samples,and the data on myopia included 367906 samples.The OR values were used to evaluate the causal effect of time spent outdoors in summer on myopia risk.Meanwhile,the robustness and pleiotropy of the effect estimates of the heterogeneity and sensitivity analysis were also analyzed.Results The results of inverse variance weighted(IVW)random effects after the analysis based on 33 SNPs were:OR=0.6049522;95%CI:0.527-0.693;P=4.959237×10^(-13).It was found that there was a causal relationship between time spent outdoors in summer and myopia.At the same time,there was some heterogeneity(I^(2)=0.42)and no significant pleiotropy(intercept=-0.0066,SE=0.00482,P=0.182)in the effect estimation.The IVW analysis results showed that shorter time spent outdoors in summer could increase the risk of myopia.Meanwhile,the analysis results based on the weighted median(WM)method and MR-Egger regression also resulted in similar results.The sensitivity analysis showed that genetic pleiotropy did not induce bias in the results.In summary,for every one standard deviation decrease in the time spent outdoors in summer after the logarithmic transformation,the risk of myopia increased by 39%.Conclusion There may be a negative causal relationship between time spent outdoors in summer and myopia.

关 键 词：孟德尔随机化 夏日户外时间 近视 因果关系 

分 类 号：R778.1[医药卫生—眼科]