生物硫醇的选择性检测研究与应用  

Investigation and application for selective detection of biothiols

作　　者：伍博文 刘依云 饶渝 辛怡 吴玲[1] 曹忠[1] Wu Bo-wen;Liu Yi-yun;Rao Yu;Xin Yi;Wu Ling;Cao Zhong(Hunan Provincial Key Laboratory of Materials Protection for Electric Power and Transportation&Hunan Provincial Key Laboratory of Cytochemistry,School of Chemistry and Chemical Engineering,Changsha University of Science and Technology,Changsha 410114,China)

机构地区：[1]长沙理工大学化学化工学院,电力与交通材料保护湖南省重点实验室,细胞化学湖南省重点实验室,湖南长沙410114

出　　处：《化学传感器》2024年第2期1-13,共13页Chemical Sensors

基　　金：国家自然科学基金(No.31527803);湖南省自然科学基金(No.2020JJ4559);湖南省教育厅科学研究项目(Nos.21A0182,21C0195);长沙理工大学大学生创新创业训练计划项目(No.HX202407)。

摘　　要：半胱氨酸(Cys)、同型半胱氨酸(Hcy)和谷胱甘肽(GSH)等生物硫醇在调节生物体的重要功能中起着重要作用,实时监测它们的生物含量可以帮助诊断各种疾病。但三者具有相近的化学结构和性质导致区分难度大,因此,发展快速灵敏且可区分三种生物硫醇的生物传感器非常重要。该文总结了近年来检测生物硫醇的方法,对比了不同传感材料与不同分析方法对生物硫醇之间的检测性能差异,阐述了生物硫醇传感分析的发展、应用前景和挑战,旨在为研发新型传感器提供一种可行的思路。Biothiols such as cysteine(Cys),homocysteine(Hcy)and glutathione(GSH)play an important role in regulating vital functions of organisms.Real-time monitoring of their biological levels can help diagnose various diseases.However,the similarity in chemical structure and properties among the three makes it difficult to differentiate between them.Therefore,it is crucial to develop rapid,sensitive,and distinguishable biosensors for the three biothiols.This paper summarizes the methods used to detect biothiols in recent years,compares the differences in detection performance between different sensing materials and analytical methods,and elaborates on the development,application prospects,and challenges of biothiol sensing.The aim is to provide a feasible approach for the development of new types of sensors.

关 键 词：生物硫醇 生物传感器 传感材料 分析方法 选择性检测 

分 类 号：R313[医药卫生—基础医学] TP212.3[自动化与计算机技术—检测技术与自动化装置]