基于普鲁士蓝的生物医学检测研究与应用  

Research and application of prussian blue based biomedical detection

作　　者：蔡蕊 廖姝琪 吴玲[1] 王晶晶 饶渝 曹忠[1] Cai Rui;Liao Shu-qi;Wu Ling;Wang Jing-jing;Rao Yu;Cao Zhong(Hunan Provincial Key Laboratory of Materials Protection for Electric Power and Transportation&Hunan Provincial Key Laboratory of Cytochemistry,School of Chemistry and Chemical Engineering,Changsha University of Science and Technology,Changsha 410114,China)

机构地区：[1]长沙理工大学化学化工学院,电力与交通材料保护湖南省重点实验室,细胞化学湖南省重点实验室,湖南长沙410114

出　　处：《化学传感器》2024年第2期14-25,共12页Chemical Sensors

基　　金：国家自然科学基金(No.31527803);湖南省自然科学基金(No.2020JJ4559);湖南省教育厅科学研究项目(Nos.21A0182,21C0195);长沙理工大学研究生科研创新项目(No.CX20230921)。

摘　　要：普鲁士蓝纳米颗粒(PBNPs)作为一种独特的纳米材料,展现出了卓越的稳定性、生物安全性及生物相容性特质。其显著优势在于,通过相对简便的方法和精细调控,PBNPs能够展现出多样化的纳米结构,包括球形、核壳结构、立方体等形态。不仅如此,表面改性策略为PBNPs的进一步开发和应用提供了有力支撑,这些策略在生物成像和传感等领域展现出了广泛的应用潜力。该文旨在深入剖析和总结当前PBNPs的合成技术、表面工程策略的最新进展,以及其在生物领域内的应用前景和未来发展趋势。通过对现有文献的综合分析,该文提出一种预见性的展望,即基于普鲁士蓝纳米颗粒驱动的生物应用将不断演进,并最终融入到一个集生物成像、化学传感、治疗于一体的综合治疗诊断平台中,推动生物医学领域的创新与发展。As a unique nanomaterial,Prussian blue nanoparticles(PBNPs)exhibit remarkable stability,biosafety,and biocompatibility.Their significant advantage lies in their ability to display diverse nanostructures,ranging from spherical shapes,core-shell structures,and cubic morphologies,through relatively simple methods and precise tuning.Furthermore,novel surface functionalization strategies provide robust support for the further development and application of PBNPs,demonstrating extensive potential in fields such as bioimaging and sensing.This article aims to provide an in-depth analysis and summary of the current advancements in PBNPs synthesis techniques,surface engineering strategies,as well as their application prospects and future trends in the biological domain.Through a comprehensive analysis of existing literature,we propose a predictive vision where PBNP-driven biological applications will continuously evolve,ultimately integrating into a comprehensive therapeutic diagnostic platform that combines bioimaging,chemical sensing,and therapy,thus driving innovation and progress in the field of biomedicine.

关 键 词：普鲁士蓝 合成方法 生物成像 化学传感器 

分 类 号：R318[医药卫生—生物医学工程] TP212[医药卫生—基础医学]