双(4-氟苯基)溴甲烷的合成方法研究  

Study on Synthesis Method of Bis(4-fluorophenyl)bromomethane

作　　者：段义杰 赵海桥 DUAN Yijie;ZHAO Haiqiao(Shandong Fangming Pharmaceutical Group Co.,Ltd.,Heze,Shandong 274000,China)

机构地区：[1]山东方明药业集团股份有限公司,山东菏泽274000

出　　处：《浙江化工》2024年第12期38-42,共5页Zhejiang Chemical Industry

摘　　要：目的:开发一种盐酸氟桂利嗪关键中间体双(4-氟苯基)溴甲烷的合成新方法。方法:以相对廉价易得的4,4'-二氟二苯甲酮为起始原料,经还原、溴代得到双(4-氟苯基)溴甲烷。结果:产物经^(1)H NMR确证其结构,反应总收率为94.61%,产品经HPLC分析,纯度达96%以上。结论:该合成方法操作简单易行,产品纯度高、收率高、成本低,操作安全,避免产生大量污水,适合工业化生产。Objective:To develop a new method for the synthesis of bis(4-fluorophenyl)bromomethane,a key intermediate of flunarizine hydrochloride.Methods:Bis(4-fluorophenyl)bromomethyl was obtained by reduction and bromination of 4,4'-difluorobenzophenone,which was relatively cheap and readily available.Results:The structure of the product was confirmed by ^(1)H NMR,the total yield of the reaction was 94.61%,and the purity of the product was more than 96%by HPLC analysis.Conclusion:The synthesis method is simple and easy to operate,the product has high purity,high yield,low cost,safe operation,avoids a large amount of sewage,and is suitable for industrial production.

关 键 词：盐酸氟桂利嗪 双(4-氟苯基)溴甲烷 4 4-二氟二苯甲酮 合成 

分 类 号：TQ463[化学工程—制药化工]