EBV非编码RNA的功能及其机制  

The function and mechanism of EBV non-coding RNA in cancers

作　　者：何江 熊炜[2] 李欣 孙仑泉[1,4] HE Jiang;XIONG Wei;LI Xin;SUN LunQuan(Xiangya Cancer Center,Xiangya Hospital,Central South University,Key Laboratory of Molecular Radiation Oncology Hunan Province,Hunan international Science and Technology Cooperation Base of Precision Medicine for Cancer,Changsha 410008,China;Cancer Research Institute,Central South University,Changsha 410078,China;Shenzhen Hospital,Southern Medical University,Shenzhen 518000,China;Institute of Geriatric Oncology,National Clinical Research Center for Geriatric Diseases(Xiangya Hospital),Changsha 410008,China)

机构地区：[1]中南大学湘雅肿瘤医学中心,分子放射肿瘤学湖南省重点实验室,湖南省肿瘤精准医学国际科技合作基地,长沙410008 [2]中南大学肿瘤研究所,长沙410078 [3]南方医科大学深圳医院,深圳518000 [4]国家老年疾病临床研究中心(湘雅医院)老年肿瘤研究所,长沙410008

出　　处：《中国科学：生命科学》2024年第12期2298-2310,共13页Scientia Sinica(Vitae)

基　　金：湖南省自然科学基金(批准号:2021JC0002,2023JJ30880)资助。

摘　　要：EB病毒(Epstein-Barr virus,EBV)属于γ疱疹病毒亚科,在人群中广泛流行,与鼻咽癌、胃癌和淋巴瘤等多种恶性肿瘤的发生密切相关.然而,EBV致瘤的分子机制仍不清楚.EBV非编码RNA包括EBV长非编码RNAs(EBV long non-coding RNAs,EBV lncRNAs)、EBV编码小RNAs(EBV-encoded small RNAs,EBERs)和EBV微小RNA(EBV microRNAs,EBV miRNAs).通过与潜在靶基因相互作用,EBV非编码RNA在病毒复制与潜伏、肿瘤细胞存活、增殖、转移和免疫逃逸等方面扮演重要角色,是近年来的研究热点.本文就EBV lncRNAs,EBERs和EBV miRNAs在EBV相关肿瘤中的功能及其介导的信号通路进行综述,并对该领域存在的问题进行讨论,以期为靶向EBV非编码RNA的临床应用提供新思路.Epstein-Barr virus(EBV)is classified within the gamma herpesvirus subfamily and is prevalent in the human population,exhibiting a significant association with various malignancies,including nasopharyngeal carcinoma,gastric cancer,and lymphoma.Nevertheless,the molecular mechanisms that drive EBV-associated carcinogenesis remain inadequately understood.EBV non-coding RNAs include long non-coding RNAs(EBV lncRNAs),EBV-encoded small RNAs(EBERs),and EBV microRNAs(miRNAs).Epstein-Barr virus(EBV)non-coding RNAs significantly influence various biological processes,including viral replication,latency,tumor cell survival,proliferation,metastasis,and immune evasion by their interactions with potential target genes.This area of research has garnered considerable attention from the EBV research community in recent years.In this review,we provide a comprehensive summary of the functions and signaling pathways associated with EBV non-coding RNAs,while also discussing critical issues within the field.We aim to offer novel insights for the clinical application of targeting EBV non-coding RNAs.

关 键 词：EBV EBV非编码RNA EBV长非编码RNA EBV编码小RNA EBV编码微小RNA 

分 类 号：R373[医药卫生—病原生物学]