基于BMP和SIRT信号通路探讨中医药治疗慢性肾脏病血管钙化的作用机制  

Mechanism of traditional Chinese medicine in treating vascular calcification in chronic kidney disease based on BMP and SIRT signaling pathways

作　　者：孙天昊 张雯 李静[1,2] 孙禹新 董鸿朔 杨洪涛 SUN Tian-hao;ZHANG Wen;LI Jing;SUN Yu-xin;DONG Hong-shuo;YANG Hong-tao(First Teaching Hospital of Tianjin University of Traditional Chinese Medicine,Tianjin 300381,China;National Clinical Research Center for Chinese Medicine Acupuncture and Moxibustion,Tianjin 300381,China)

机构地区：[1]天津中医药大学第一附属医院,天津300381 [2]国家中医针灸临床医学研究中心,天津300381

出　　处：《中国中药杂志》2024年第23期6302-6310,共9页China Journal of Chinese Materia Medica

基　　金：国家自然科学基金项目(82274441)。

摘　　要：血管钙化显著增加了慢性肾脏病(chronic kidney disease, CKD)患者的心血管疾病发病率和全因死亡率,严重影响患者的生命健康。然而,CKD血管钙化的机制尚不完善,可供选择的治疗药物相对有限。研究发现,血管平滑肌细胞由收缩表型转变为成骨样表型是CKD血管钙化的关键环节。随着对钙化相关发病机制的探索不断深入,已有研究证实骨形态发生蛋白和沉默信息调节因子信号通路可以通过调控血管平滑肌细胞成骨转分化参与血管钙化的过程。在漫长的医疗探索中,中医药积累了大量防治肾脏疾病的宝贵经验。现代研究表明,中医药凭借其多通路、多靶点、低毒性的特点,在防治CKD血管钙化和改善患者生活质量等方面中显示出一定的优势。因此,该文研究将立足于骨形态发生蛋白和沉默信息调节因子信号通路,对中医药防治CKD血管钙化的最新研究进展情况进行介绍,以期为CKD血管钙化的中医药临床诊治和相关基础研究提供思路。Vascular calcification significantly increases the incidence of cardiovascular disease and all-cause mortality patients with chronic kidney disease(CKD),severely affecting their health and lifespan.However,the mechanisms underlying vascular calcification in CKD remain incompletely understood,and the available therapeutic agents are limited.Research has found that the transformation of vascular smooth muscle cells(VSMCs)from a contractile phenotype to an osteoblast-like phenotype is a key step in CKD-related vascular calcification.As research on the pathogenesis of calcification progresses,it has been demonstrated that bone morphogenetic protein(BMP)and silent information regulator(SIRT)signaling pathways can participate in the process of vascular calcification by regulating the osteogenic transdifferentiation of VSMCs.Traditional Chinese medicine(TCM)has accumulated a wealth of valuable experience in the prevention and treatment of kidney diseases over centuries.Modern research indicates that TCM,with its multipathway,multi-target,and low-toxicity properties,has shown certain advantages in the prevention and treatment of CKD-related vascular calcification and in improving patients′quality of life.Therefore,in this study,we will introduce the latest research progress of TCM in preventing and treating CKD-related vascular calcification,particularly focusing on the BMP and SIRT signaling pathways,with the aim of providing ideas for the clinical diagnosis and treatment of CKD-related vascular calcification with TCM and related basic research.

关 键 词：慢性肾脏病 血管钙化 骨形态发生蛋白 沉默信息调节因子 中医药 

分 类 号：R277.5[医药卫生—中医学]