MRI评价恶性肿瘤免疫检查点抑制剂神经系统免疫相关不良反应中国专家共识  

Chinese expert consensus on the evaluation of neurological immune-related adverse reactions in malignant tumors treated with immune checkpoint inhibitors by MRI

作　　者：中华医学会放射学分会分子影像学组 中华医学会放射学分会磁共振学组 中华医学会放射学分会神经学组 《磁共振成像》编委会 孙洪赞[2] 居胜红[3] 龚明福 黄薇园 李伟华 佘德君[7] 唐作华[8] 王星皓 徐臣 Molecular Imaging Group of Chinese Society of Radiology of Chinese Medical Association;MRI Group of Chinese Society ofRadiology Chinese Medical Association;Neurology Group of Chinese Society of Radiology Chinese Medical Association;EditorialBoard of Chinese Journal of Magnetic Resonance Imaging;SUN H Z;JU S H(不详;Department of Radiology,Shengjing Hospital Affiliated to China Medical University,Shenyang 110004,China;Department of Radiology,Zhongda Hospital Affiliated to Southeast University,Nanjing 210009,China)

机构地区：[1]不详 [2]中国医科大学附属盛京医院放射科,沈阳110004 [3]东南大学附属中大医院放射科,南京210009 [4]陆军军医大学第二附属医院 [5]海南医科大学附属海南医院 [6]深圳市第二人民医院/深圳大学第一附属医院 [7]福建医科大学附属第一医院 [8]复旦大学附属眼耳鼻喉科医院 [9]首都医科大学附属北京友谊医院 [10]中国医科大学附属盛京医院

出　　处：《磁共振成像》2024年第12期1-9,18,共10页Chinese Journal of Magnetic Resonance Imaging

基　　金：国家自然科学基金项目(编号:82220108007、92359304、82330060、92059202)。

摘　　要：近年来,癌症免疫疗法,尤其是免疫检查点抑制剂(immune checkpoint inhibitors,ICIs),已成为肿瘤治疗领域的重要突破,显著改善患者预后。然而,免疫相关不良事件(immune-related adverse events,irAEs)的发生,尤其是神经系统irAEs,是癌症免疫治疗的主要限制之一,相关死亡率超过5%。MRI在检测和评估神经系统irAEs中具有关键作用。然而,国内尚缺乏针对ICIs引起的神经系统irAEs在MRI检查及诊断中的规范化共识。为此,中华医学会放射学分会分子影像学组、磁共振学组、神经学组及《磁共振成像》编委会致力于制订针对ICIs引起的神经系统irAEs在MRI检查方案和诊断报告等方面的规范化共识。在借鉴文献、专家经验以及成员的内部讨论之后,本委员会达成此共识,旨在为影像和临床医生提供更为准确的实证支持,推动MRI技术在诊断神经系统irAEs中的应用。In recent years,cancer immunotherapy,especially immune checkpoint inhibitors(ICIs),has become an important breakthrough in tumor treatment,significantly improving patient prognosis.However,the occurrence of immune-related adverse events(irAEs),particularly those affecting the nervous system,is one of the main limitations of cancer immunotherapy,with an associated mortality rate exceeding 5%.MRI plays a key role in detecting and assessing neurological irAEs.However,there is currently a lack of standardized consensus in China regarding MRI examination and diagnosis of neurological irAEs caused by ICIs.To address this,the Molecular Imaging Group,Magnetic Resonance Group,and Neurology Group of the Radiology Branch of the Chinese Medical Association,along with the Editorial Board of Chinese Journal of Magnetic Resonance Imaging,are committed to formulating a consensus on MRI examination and diagnostic reporting for neurological irAEs caused by ICIs.After reviewing the literature,expert experience,and internal member discussions,this committee has reached a consensus aimed at providing more accurate empirical support for imaging and clinical physicians and promoting the application of MRI technology in the diagnosis of neurological irAEs.

关 键 词：磁共振成像 免疫检查点抑制剂 神经系统免疫相关不良反应 临床应用 专家共识 

分 类 号：R445.2[医药卫生—影像医学与核医学] R73[医药卫生—诊断学]