MRI评价恶性肿瘤免疫检查点抑制剂内分泌系统免疫相关不良反应中国专家共识  

Chinese expert consensus on MRI evaluation of endocrine system immune-related adverse events induced by immune checkpoint inhibitors in malignant tumors

作　　者：中华医学会放射学分会分子影像学组 中华医学会放射学分会磁共振学组 中华医学会放射学分会神经学组 《磁共振成像》编委会 孙洪赞[2] 居胜红[3] 王守巨 王星皓 徐臣 颜林枫 Molecular Imaging Group of Chinese Society of Radiology of Chinese Medical Association;MRI Group of Chinese Society ofRadiology Chinese Medical Association;Neurology Group of Chinese Society of Radiology Chinese Medical Association;EditorialBoard of Chinese Journal of Magnetic Resonance Imaging;SUN H Z;JU S H(不详;Department of Radiology,Shengjing Hospital Affiliated to China Medical University,Shenyang 110004,China;Department of Radiology,Zhongda Hospital Affiliated to Southeast University,Nanjing 210009,China)

机构地区：[1]不详 [2]中国医科大学附属盛京医院放射科,沈阳110004 [3]东南大学附属中大医院放射科,南京210009 [4]南京医科大学第一附属医院 [5]首都医科大学附属北京友谊医院 [6]中国医科大学附属盛京医院 [7]空军军医大学唐都医院

出　　处：《磁共振成像》2024年第12期19-27,共9页Chinese Journal of Magnetic Resonance Imaging

基　　金：国家自然科学基金项目(编号:82220108007、92359304、82330060、92059202)。

摘　　要：免疫检查点抑制剂(immune checkpoint inhibitors,ICIs)通过重新激活效应T细胞以发挥其肿瘤细胞杀伤功能,从而展现出强大的抗肿瘤作用。然而,这种调控免疫应答机制同时也可能导致免疫细胞的过度活化,从而引发机体的自身免疫损伤,即免疫相关不良反应(immune-related adverse events,irAEs)。这些不良反应中,以内分泌系统尤为常见,主要影响甲状腺、垂体、肾上腺等腺体,造成机体功能紊乱。MRI在内分泌系统irAEs的早期诊断和病情评估中扮演重要角色。然而,目前国内尚未形成针对ICIs引起的内分泌系统irAEs在MRI检查及诊断中的规范化共识。为此,中华医学会放射学分会分子影像学组、磁共振学组、神经学组及《磁共振成像》编委会联合成立了专家委员会。通过广泛阅读文献、结合专家经验以及内部讨论,委员会最终形成了此共识。本共识的目标在于为影像和临床医生通过MRI诊断内分泌系统irAEs提供指导和支持。Immune checkpoint inhibitors(ICIs)demonstrate potent anti-tumor effects by reactivating effector T cells to eliminate cancer cells.However,this modulation of the immune response can also lead to activation of immune cells,triggering autoimmune damage,known as immune-related adverse events(irAEs).Among these adverse reactions,endocrine system disorders are particularly common,primarily affecting endocrine glands such as the thyroid,pituitary,and adrenal glands,leading to endocrine dysfunction.MRI plays a crucial role in the early diagnosis and assessment of endocrine system irAEs.However,there is currently no standardized consensus in China regarding MRI examination and diagnosis of endocrine system irAEs caused by ICIs.For this purpose,the Molecular Imaging Group,Magnetic Resonance Group,and Neurology Group of the Radiology Branch of the Chinese Medical Association,together with the Editorial Board of Chinese Journal of Magnetic Resonance Imaging,jointly established an expert committee.Drawing extensively from the literature,combined with expert experience and internal discussions,the committee ultimately developed this consensus.The aim of this consensus is to provide guidance and support to radiologists and clinicians in diagnosing endocrine system irAEs using MRI.

关 键 词：磁共振成像 免疫检查点抑制剂 内分泌系统免疫相关不良反应 临床应用 专家共识 

分 类 号：R445.2[医药卫生—影像医学与核医学] R73[医药卫生—诊断学]