MRI评价恶性肿瘤免疫检查点抑制剂腹部免疫相关不良反应中国专家共识  

Chinese expert consensus on the evaluation of abdominal immune-related adverse reactions in malignant tumors treated with immune checkpoint inhibitors by MRI

作　　者：中华医学会放射学分会分子影像学组 中华医学会放射学分会磁共振学组 中华医学会放射学分会腹部学组 《磁共振成像》编委会 孙洪赞[2] 居胜红[3] 雷晶[4] 李丹 李海明 沈亚琪 孙少凯 王良 王星皓 徐臣 薛华丹[11] 张晓磊 Molecular Imaging Group of Chinese Society of Radiology of Chinese Medical Association;MRI Group of Chinese Society ofRadiology Chinese Medical Association;Abdominal Group of Chinese Society of Radiology Chinese Medical Association;EditorialBoard of Chinese Journal of Magnetic Resonance Imaging;SUN H Z;JU S H(不详;Department of Radiology,Shengjing Hospital Affiliated to China Medical University,Shenyang 110004,China;Department of Radiology,Zhongda Hospital Affiliated to Southeast University,Nanjing 210009,China)

机构地区：[1]不详 [2]中国医科大学附属盛京医院放射科,沈阳110004 [3]东南大学附属中大医院放射科,南京210009 [4]中国医学科学院北京协和医学院 [5]中山大学附属第五医院 [6]复旦大学附属肿瘤医院 [7]华中科技大学同济医学院附属同济医院 [8]天津医科大学医学影像学院 [9]首都医科大学附属北京友谊医院 [10]中国医科大学附属盛京医院 [11]中国医学科学院北京协和医院 [12]汕头大学医学院第二附属医院

出　　处：《磁共振成像》2024年第12期28-37,共10页Chinese Journal of Magnetic Resonance Imaging

基　　金：国家自然科学基金项目(编号:82220108007、92359304、82330060、92059202)。

摘　　要：免疫检查点抑制剂(immune checkpoint inhibitors,ICIs)的问世,为恶性肿瘤的免疫治疗开辟了新纪元。尽管如此,伴随而来的免疫相关不良事件(immune-related adverse events,irAEs)却成为了治疗过程中的一大挑战。其中,腹部是irAE最常见的发生部位,腹部irAE也是最常导致免疫治疗中止的原因。MRI在检测和评估腹部irAEs中扮演着关键角色。因此,早期通过MRI对腹部irAEs进行诊断和评估至关重要。然而,国内目前缺乏针对ICIs引起的腹部irAEs在MRI检查及诊断中的规范化共识。为此,中华医学会放射学分会分子影像学组、腹部学组、磁共振学组及《磁共振成像》编委会致力于制订针对ICIs引起的腹部irAEs在MRI扫描方案、诊断报告等方面的共识。本委员会在借鉴文献、专家经验和委员会成员内部讨论的基础上,最终达成此共识。本共识旨在规范MRI在肿瘤免疫治疗中的应用,优化腹部irAEs的评估,为临床提供坚实的影像学依据。The advent of Immune checkpoint inhibitors(ICIs)has heralded a new era in the immunotherapy of malignant tumors.Despite this,the accompanying immune-related adverse events(irAEs)have become a major challenge in the treatment process.Among them,the abdomen is the most common site for irAEs to occur,and abdominal irAEs are also the most common reason for the discontinuation of immunotherapy.MRI plays a key role in detecting and evaluating abdominal irAEs.Therefore,early diagnosis and assessment of abdominal irAEs through MRI is crucial.However,there is currently a lack of standardized consensus on MRI examination and diagnosis of abdominal irAEs caused by ICIs in China.To this end,the Molecular Imaging Group,Abdominal Group,and Magnetic Resonance Group of the Radiology Branch of the Chinese Medical Association,as well as the Editorial Board of Chinese Journal of Magnetic Resonance Imaging are committed to formulating a consensus on MRI scanning protocols and diagnostic reporting for abdominal irAEs caused by ICIs.This committee has reached this consensus based on literature,expert experience,and internal discussions among committee members.The consensus aims to standardize the application of MRI in tumor immunotherapy,optimize the assessment of abdominal irAEs,and provide a solid imaging basis for clinical practice.

关 键 词：磁共振成像 免疫检查点抑制剂 腹部免疫相关不良反应 临床应用 专家共识 

分 类 号：R445.2[医药卫生—影像医学与核医学] R73[医药卫生—诊断学]