妊娠期糖尿病孕妇血清IL-6、OPN水平与骨代谢标志物相关性分析  

Correlation analysis of serum IL-6,OPN levels and bone metabolism markers in pregnant women with gestational diabetes mellitus

作　　者：乔鹏艳 何李明 苏丹 英晓菲 胡丽燕 Qiao Pengyan;He Liming;Su Dan;Ying Xiaofei;Hu Liyan(Obstetrical Department,Shanxi Children’s Hospital,Shanxi Maternal and Child Health Hospital,Taiyuan 030000,China)

机构地区：[1]山西省儿童医院山西省妇幼保健院产科,太原030000 [2]山西白求恩医院同济山西医院骨科,太原030032

出　　处：《中华内分泌外科杂志（中英文）》2024年第6期789-793,共5页Chinese Journal of Endocrine Surgery

基　　金：山西省卫生健康委员会课题计划项目(IRB-KY-2019-002)。

摘　　要：目的分析妊娠期糖尿病(GDM)孕妇血清白介素-6(IL-6)、骨桥蛋白(OPN)水平与骨代谢标志物相关性。方法特选取2020年8月至2022年5月于山西省儿童医院收治的GDM孕妇89例作为观察组,另选取同期性健康体检的85例正常妊娠孕妇为对照组。对比两组临床资料并分析发生GDM相关因素,检测两组血清IL-6、OPN及骨代谢标志物β胶原特殊序列(β-CTX)、I型原胶原分子N端前肽(PINP)、N端中段骨钙素(N-MID)、空腹血糖(FBG)及空腹胰岛素(FINS)水平,计算胰岛素抵抗指数(HOMA-IR),并分析血清IL-6、OPN分别与β-CTX、PINP、N-MID的关系。结果观察组年龄、孕次、孕前身体质量指数(BMI)均高于对照组,糖尿病家族史人数多于对照组,两组比较均存在统计学意义(t=14.31、31.46、9.47、10.33,P均<0.05);经Logistic回归分析结果显示,年龄越大、孕次越多,孕前BMI越高,糖尿病家族史人数较多均为发生GDM的独立危险因素[(OR(95%CI)=1.569(1.370~1798)、8.533(5.067~14.367)、1.460(1.301~1.639)、3.677(1.611~8.396),P均<0.05)];观察组血清IL-6、OPN、FBG、FINS及HOMA-IR水平均高于对照组(t=16.64、24.76、10.97、11.01、55.70,P均<0.05);观察组β-CTX高于对照组,PINP以及N-MID均低于对照组(t=3.64、12.19、12.52,P<0.05);Spearman相关性分析得,血清IL-6、OPN分别与β-CTX呈正相关(r=0.781、0.746,P均<0.05);血清IL-6、OPN分别与PINP、N-MID呈负相关(r=-0.264、-0.305;-0.208、-305,P均<0.05)。结论在GDM孕妇中,血清IL-6、OPN分别与β-CTX呈正相关,血清IL-6、OPN分别与PINP、N-MID呈负相关,上述指标均可作为病情监测的指标,对于保障GDM孕妇的健康有重要作用。ObjectiveTo analyze the correlation between serum interleukin-6(IL-6)and osteopontin(OPN)levels and bone metabolism markers in pregnant women with gestational diabetes mellitus.MethodsA total of 89 pregnant women with GDM who were admitted to Shanxi Children’s Hospital from Aug.2020 to May.2022 were selected as the observation group,and 85 normal pregnant women who underwent regular health examination were selected as the control group.Clinical data of the two groups were compared and GDM related factors were analyzed.Serum IL-6,OPN,bone metabolic markersβcollagen special sequence(β-CTX),type I procollagen N-terminal propeptide(PINP),n-terminal mid-section osteocalcin(N-MID),fasting blood glucose(FBG)and fasting insulin(FINS)levels of the two groups were detected.Insulin resistance index(HOMA-IR)was calculated,and the relationship between serum IL-6,OPN andβ-CTX,PINP and N-MID was analyzed.ResultsThe age,gestational times and pre-pregnancy BMI of the observation group were higher than those of the control group,and the family history of diabetes was more than that of the control group,with statistical significance between the two groups(t=14.31,31.46,9.47,10.33,P<0.05).Logistic regression analysis showed that the older the age and the more pregnancies,the higher the pre-pregnancy BMI.Independent risk factors for developing GDM were associated with a large family history of diabetes mellitus[(OR(95%CI)=1.569(1.370-1798),8.533(5.067-14.367),1.460(1.301-1.639),3.677(1.611-8.396).P<0.05)];Serum levels of IL-6,OPN,FBG,FINS and HOMA-IR in observation group were higher than those in control group(t=16.64,24.76,10.97,11.01,55.70,all P<0.05).Theβ-CTX of observation group was higher than that of control group,and the PINP and N-MID of observation group were lower than that of control group(t=3.64,12.19,12.52,P<0.05).Spearman correlation analysis showed that serum IL-6 and OPN were positively correlated withβ-CTX(r=0.781,0.746,P<0.05).Serum IL-6 and OPN were negatively correlated with PINP and N-MID(r=-0.264,-0.305;-

关 键 词：妊娠期糖尿病 孕妇 白介素-6 骨桥蛋白 骨代谢标志物 

分 类 号：R714.256[医药卫生—妇产科学]