雄激素性脱发相关信号通路的研究进展  

Advances in signaling pathways associated with androgenetic alopecia

作　　者：唐忠一 胡志威 李王舸 刘培强 方名扬 钟杰 席梓维 果磊[1] Tang Zhongyi;Hu Zhiwei;Li Wangge;Liu Peiqiang;Fang Mingyang;Zhong Jie;Xi Ziwei;Guo Lei(Department of Burn and Plastic Surgery,the First Affiliated Hospital of Chongqing Medical University,Chongqing 400016,China)

机构地区：[1]重庆医科大学附属第一医院烧伤整形科,重庆400016

出　　处：《中华内分泌外科杂志（中英文）》2024年第6期914-916,共3页Chinese Journal of Endocrine Surgery

基　　金：重庆市科卫联合中医药科研项目(2019ZY023405)。

摘　　要：雄激素性脱发(AGA)是目前最常见的脱发疾病,是遗传因素与环境因素共同作用的结果,表现为头顶部及额颞区周围的毛囊微型化,最后致毛发减少或消失。AGA发病机制与多种信号通路密切相关,其中包括Wnt/β-catenin信号通路、骨形成蛋白(BMP)信号通路、胰岛素样生长因子(IGF)信号通路、成纤维细胞生长因子(FGF)信号通路、刺猬(SHH)信号通路等。在这些信号通路中有多种细胞因子参与其中,包括β-catenin、BMP2、IGF-1及FGF5等。深入研究AGA相关信号通路和相关细胞因子,有助于对AGA发病机制全面认识,为发现新的信号通路提供一定理论基础,为治疗AGA提供新的研究方向。Androgenetic alopecia(AGA)is currently the most common hair loss disease,which is the result of a combination of genetic and environmental factors,and manifests itself as miniaturization of hair follicles around the top of the head and frontotemporal region,which eventually leads to hair reduction or disappearance.The pathogenesis of AGA is closely related to a variety of signaling pathways,which include the Wnt/β-catenin signaling pathway,bone-forming protein(BMP)signaling pathway,insulin-like growth factor(IGF)signaling pathway,fibroblast growth factor(FGF)signaling pathway,hedgehog(SHH)signaling pathway,and so on.Several cytokines are involved in these signaling pathways,includingβ-catenin,BMP2,IGF-1,and FGF5.An in-depth study of AGA-related signaling pathways and related cytokines can help to provide a comprehensive understanding of the pathogenesis of AGA,provide a certain theoretical basis for the discovery of new signaling pathways,and provide a new research direction for the treatment of AGA.

关 键 词：雄激素性脱发 信号通路 细胞因子 毛发生长 

分 类 号：R758.71[医药卫生—皮肤病学与性病学]