多西环素联合阿奇霉素对恙虫病合并肺部感染疗效分析  

Effect of Doxycycline Combined with Azithromycin on the Recovery Progress of Patients with Scrub Typhus Complicated with Pulmonary Infection

作　　者：曾华彪 陈丽芳[2] ZENG Huabiao;CHEN Lifang(Pingtan Comprehensive Experimental Zone Hospital(Department of Infectious Diseases,Pingtan Branch,Fujian Union Medical College Hospital),Fuzhou 350000,China;Department of Hepatology,Meng Chao Hepatobiliary Hospital Affiliated to Fujian Medical University,Fuzhou 350000,China)

机构地区：[1]平潭综合实验区医院(福建协和医院平潭分院感染疾病科),福建福州350000 [2]福建医科大学附属孟超肝胆医院肝病科,福建福州350000

出　　处：《中华灾害救援医学》2024年第11期1294-1297,共4页Chinese Journal of Disaster Medicine

摘　　要：目的分析对于恙虫病合并肺部感染患者,多西环素与阿奇霉素联合用药方案的治疗效果。方法回顾性收集2021年2月至2024年2月于福建协和医院平潭分院就诊的100例恙虫病合并肺部感染患者的临床资料,以治疗方案为分组依据分为观察组(多西环素联合阿奇霉素,50例)和对照组(多西环素,50例)。比较两组研究对象的临床疗效、临床指标康复时间、肝功能情况、不良反应发生情况。结果观察组研究对象的临床总有效率显著高于对照组(P>0.05);观察组研究对象体温恢复正常、肺部啰音消失、焦痂脱落、肝功能恢复正常、住院所需时间更短(P<0.001)。治疗后观察组谷草转氨酶和谷丙转氨酶水平更低(P<0.001)。两组研究对象的不良反应总发生率无显著差异(P>0.05)。结论对于恙虫病合并肺部感染者,多西环素与阿奇霉素联用的治疗方案临床疗效显著,可一定程度上缩短临床症状的改善时间,促进肝功能的恢复,且安全性相对较高。Objective To analyze the therapeutic effect of the combination therapy of doxycycline and azithromycin in patients with scrub typhus complicated by pulmonary infection.Methods A retrospective collection of clinical data was conducted on 100 patients with scrub typhus complicated with pulmonary infection who visited Pingtan Branch of Fujian Union Medical College Hospital from February 2021 to February 2024.The patients were divided into an observation group(50 cases of doxycycline combined with azithromycin)and a control group(50 cases of doxycycline)based on the treatment plan.Compare the clinical efficacy,clinical indicators of rehabilitation time,liver function status,and incidence of adverse reactions between two groups of research subjects.Results The total clinical effective rate of the observation group was significantly higher than that of the control group(P>0.05);The observation group showed that the subjects'body temperature returned to normal,lung rales disappeared,scabs fell off,liver function returned to normal,and hospitalization time was shorter(P<0.001).After treatment,the observation group had lower levels of aspartate aminotransferase and alanine aminotransferase(P<0.001).There was no significant difference in the overall incidence of adverse reactions between the two study groups(P>0.05).Conclusion For patients with scrub typhus complicated with pulmonary infection,the combination therapy of doxycycline and azithromycin has significant clinical efficacy,can shorten the improvement time of clinical symptoms to a certain extent,promote the recovery of liver function,and has relatively high safety.

关 键 词：立克次体 恙虫热 肺炎 立克次体 多西环素 

分 类 号：R513.2[医药卫生—内科学]