阿尔茨海默病患者MRI表现与认知功能的关系  

Relationship between MRI Findings and Cognitive Function in Patients with Alzheimer's Disease

作　　者：李方建 陈飞 董从松[1] 李新[1] 黄锋 LI Fang-jian;CHEN Fei;DONG Cong-song;LI Xin;HUANG Feng(Imaging Department of Yancheng Third People's Hospital(The Sixth Affiliated Hospital of Nantong University),Yancheng 224008,Jiangsu Province,China)

机构地区：[1]盐城市第三人民医院(南通大学第六附属医院)影像科,江苏盐城224008

出　　处：《中国CT和MRI杂志》2025年第1期28-29,32,共3页Chinese Journal of CT and MRI

基　　金：盐城市医学科技发展计划项目(YK2021009)。

摘　　要：目的 探究阿尔茨海默病(AD)患者磁共振成像(MRI)表现与认知功能的关系。方法 回顾性分析2021年5月至2023年5月收治的78例AD患者的临床资料,患者均进行MRI检查,并使用简易智力状态检查量表(MMSE)对患者认知功能进行评估,将MMSE得分<20分的患者纳入中重度组(n=37),将MMSE得分≥20分的患者纳入轻度组(n=41),分析两组患者脑室结构体积(左海马体积、右海马体积、胼胝体体积、侧脑室体积)、侧脑室颡角宽度(左侧脑室颞角宽度、右侧脑室颞角宽度)、外侧裂宽度水平、MRI诊断结果差异。结果 中重度组患者左海马体积、右海马体积、胼胝体体积、侧脑室体积均低于轻度组(P均<0.05);中重度组患者左侧脑室颞角宽度、右侧脑室颞角宽度、外侧裂宽度均高于轻度组(P均<0.05);中重度组患者海马萎缩、脑萎缩、脑室改变发生率均高于轻度组(P均<0.05)。结论AD患者中认知功能损害严重的患者进行M RI检查后发现存在明显海马体萎缩、脑萎缩、脑室改变,AD患者MRI表现与认知功能存在联系。Objective To explore the relationship between magnetic resonance imaging(MRI)findings and cognitive function in patients with Alzheimer s disease(AD).Methods The clinical data of 78 patients with AD from May 2021 to May 2023 were retrospectively analyzed.All patients underwent MRI examination,and the cognitive function of patients was evaluated by using Mini-Mental State Examination(MMSE).Patients with MMSE score<20 points were included in moderate-to-severe group(n=37),and patients with MMSE score≥20 points were enrolled as mild group(n=41).The differences in ventricular structure volumes(left hippocampus volume,right hippocampus volume,corpus callosum volume,lateral ventricle volume),lateral ventricle temporal horn widths(left ventricle temporal horn width,right ventricle temporal horn width),lateral fissure width and MRI diagnostic results in the two groups were analyzed.Results The volumes of left hippocampus,right hippocampus,corpus callosum and lateral ventricle in moderate-to-severe group were lower than those in mild group(all P<0.05).The widths of left ventricular temporal horn,right ventricula r temporal horn and lateral fissure were higher in moderate-to-severe group than those in mild group(all P<0.05).The incidence rates of hippocampal atrophy,brain atrophy and ventricular changes in moderate-to-severe group were higher than those in mild group(P<0.05).Conclusion Patients with severe cognitive impairment among AD patients have obvious hippocampal atrophy,brain atrophy and ventricular changes after MRI examination,and MRI findings in AD patients a re associated with cognitive function.

关 键 词：阿尔茨海默病 磁共振成像 认知功能 海马体 

分 类 号：R445.2[医药卫生—影像医学与核医学]