非纵隔T淋巴母细胞淋巴瘤二例并文献复习  

Two Cases of Non-mediastinal T-lymphoblastic Lymphoma and Review of the Literature

作　　者：王晓燕 华子萱 朱天祺 张俏俏 谢婷婷[1] 成官迅[1] 黎永滨[1] WANG Xiao-yan;HUA Zi-xuan;ZHU Tian-qi;ZHANG Qiao-qiao;XIE Ting-ting;CHENG Guan-xun;LI Yong-bin(Department of Medical Imaging,Peking University Shenzhen Hospital,Shenzhen 518036,Guangdong Province,China)

机构地区：[1]北京大学深圳医院医学影像科,广东深圳518036

出　　处：《罕少疾病杂志》2025年第1期1-3,8,共4页Journal of Rare and Uncommon Diseases

基　　金：北京大学深圳医院科研基金资助课题(青年种子基金JCYJ2020007);北京大学深圳医院科研启动金资助(KYQD2023301);DCE-MRI乳腺癌精准定量及智能诊断研究(NMED2021MS-01-001);深圳市科创委基础研究面上项目(JCYJ20210324110211031);深圳市高水平医院专项建设经费资助。

摘　　要：目的探讨非纵隔T淋巴母细胞淋巴瘤(T-LBL)的临床特点及影像学征象,提高对T-LBL的认识。方法回顾2例非纵隔T-LBL患者的临床表现、实验室及影像学检查、病理结果并复习相关文献,总结非纵隔T-LBL的临床及影像特点。结果2例患者的病变部位分别为全身多发浅表淋巴结、左侧眼外肌,例1有B症状,CT显示双侧腋窝、锁骨上区、纵隔、腹腔内、腹膜后及双侧腹股沟区多发淋巴结轻中度肿大,例2临床症状为左眼视物模糊2月,MR显示左侧多发眼外肌弥漫性肌腹增粗并包绕视神经、延伸至左侧鞍旁,经穿刺活检、免疫组化检查、骨髓穿刺等检查证实为T-LBL。结论非纵隔T-LBL临床罕见,常发生于青年男性,CT及MRI显示病灶多发,呈多病灶、多中心性生长,病变形态规则,密度/信号较均匀,增强后轻-中度强化且强化均匀。Objective To investigate the clinical and imaging features of non-mediastinal T-lymphoblastic lymphoma(T-LBL)in order to improve the understanding of T-LBL.Methods The clinical presentation,laboratory tests,imaging and pathological results of two cases of non-mediastinal T-LBL and the relevant literatures were reviewed and analyzed.Results Multiple superficial lymph nodes enlargement was seen in case 1,and left extraocular muscles thickening was demonstrated in case 2,respectively.B symptoms could be seen in case 1.Mild to moderate enlargement of multiple lymph nodes in both axillae,supraclavicular area,mediastinum,intra-abdominal cavity,retroperitoneal and bilateral inguinal area were found in case 1.The clinical symptom of case 2 was blurred vision of left eye for two months.Diffuse thickening of left extraocular muscles were found,mostly involve the abdomen portion,and the optic nerve was surrounded and the left parasellar area was involved.Cases were confirmed of T-LBL by needle biopsy,immunohistochemistry,bone marrow aspiration and other examinations.Conclusion Non-mediastinal T-LBL is rare in clinical practice,commonly occurred in young adult males.Multiple lesions with polycentric growth mode were seen on CT and MR images,the lesions were regular in morphology,with homogeneous density/signal and homogeneous enhancement after contrast enhanced,mild to moderate enhancement was found.

关 键 词：T淋巴母细胞淋巴瘤 纵隔 体层摄影术 X线计算机 磁共振 

分 类 号：R445.3[医药卫生—影像医学与核医学]