TG、TPOAb、TGAb、CEA联合检测对甲状腺结节良恶性的诊断鉴别价值  

The Diagnostic and Differential Value of TG,TPOAb,TGAb,CEA Combined Detection for Benign and Malignant Thyroid Nodules

作　　者：何哲 张丽梅 刘承果 HE Zhe;ZHANG Li-mei;LIU Cheng-guo(Department of Laboratory,Kaifeng People's Hospital,Kaifeng 475000,Henan Province,China)

机构地区：[1]开封市人民医院检验科,河南开封475000

出　　处：《罕少疾病杂志》2025年第1期52-53,56,共3页Journal of Rare and Uncommon Diseases

摘　　要：目的 探讨分析甲状腺球蛋白(TG)、抗甲状腺过氧化物酶抗体(TPOAb)、甲状腺球蛋白抗体(TGAb)、癌胚抗原(CEA)联合检测对甲状腺结节良恶性的诊断鉴别价值。方法 于2022.1至2024.4期间,选取我院收治的96例甲状腺结节患者,其中包括59例良性和37例恶性结节,依次分为良性组和恶性组,检测比较两组TG、TPOAb、TGAb、CEA水平,分析联合检测的诊断鉴别价值。结果 良性组TG、TPOAb、TGAb、CEA水平较恶性组明显更低(P<0.05);良性组TG、TPOAb、TGAb阳性率低于恶性组(P<0.05);经ROC曲线分析显示,TG、TPOAb、TGAb、CEA联合检测的灵敏度、特异度分别为91.89%、94.92%,曲线下面积(AUC)为0.942,约登指数为0.863,联合检测的诊断鉴别效能明显高于单项检测(P<0.05)。结论 TG、TPOAb、TGAb、CEA联合检测的诊断鉴别价值较高,临床可采取该联合检测方式对甲状腺结节良恶性质进行鉴别。Objective To explore and analyze the diagnostic and differential value of combined detection of thyroglobulin(TG),thyroid peroxidase antibody(TPOAb),thyroglobulin antibody(TGAb),and carcinoembryonic antigen(CEA)for benign and malignant thyroid nodules.Methods From January 2022 to April 2024,96 patients with thyroid nodules admitted to our hospital,including 59 benign and 37 malignant nodules,were selected and divided into the benign group and the malignant group in turn.The levels of TG,TPOAb,TGAb and CEA in the two groups were detected and compared,and the diagnostic and differential value of combined detection was analyzed.Results The levels of TG,TPOAb,TGAb,and CEA in the benign group were significantly lower than those in the malignant group(P<0.05);The positive rates of TG,TPOAb,and TGAb in the benign group were lower than those in the malignant group(P<0.05);According to ROC curve analysis,the sensitivity and specificity of the combined detection of TG,TPOAb,TGAb,and CEA were 91.89%and 94.92%,respectively.The area under the curve(AUC)was 0.942,and the Youden index was 0.863.The diagnostic and differential efficacy of the combined detection was significantly higher than that of the single detection(P<0.05).Conclusion The combined detection of TG,TPOAb,TGAb and CEA has high diagnostic and differential value,which can be used to distinguish the good and evil characteristics of thyroid nodules in clinic.

关 键 词：甲状腺球蛋白 抗甲状腺过氧化物酶抗体 甲状腺球蛋白抗体 癌胚抗原 甲状腺结节 

分 类 号：R581[医药卫生—内分泌]