FOLR1、PSMA在正常子宫内膜、非典型增生及癌组织中的表达及临床意义  

The Expression and Clinical Significance of FOLR1 and PSMA in Normal Endometrium,Atypical Hyperplasia,and Cancer Tissues

作　　者：张星 ZHANG Xing(Department of Pathology,Fifth Affiliated Hospital of Zhengzhou University,Zhengzhou 450052,Henan Province,China)

机构地区：[1]郑州大学第五附属医院病理科,河南郑州450052

出　　处：《罕少疾病杂志》2025年第1期102-104,共3页Journal of Rare and Uncommon Diseases

摘　　要：目的 探讨叶酸受体1(FOLR1)、前列腺特异性膜抗原(PSMA)在不同子宫内膜组织中的表达情况。方法 收集2021年1月至2023年8月郑州大学第五附属医院病理科诊断为子宫内膜癌石蜡包埋标本98份、30份非典型增生子宫内膜与30份正常子宫内膜石蜡包埋标本,使用免疫组化染色检测FOLR1、PSMA。比较正常子宫内膜、非典型增生及癌组织中FOLR1、PSMA阳性表达情况,并分析子宫内膜癌患者FOLR1、PSMA阳性表达与临床病理特征的相关性。结果 子宫内膜癌FOLR1、PSMA阳性表达率高于非典型增生子宫内膜、正常子宫内膜,有统计学差异(P<0.05);非典型增生子宫内膜FOLR1、PSMA阳性表达率高于正常子宫内膜,但无统计学差异(P>0.05);不同年龄、组织学类型、分化程度子宫内膜癌患者FOLR1、PSMA阳性表达率比较,无统计学差异(P>0.05);有脉管侵犯、淋巴结转移子宫内膜癌的FOLR1、PSMA阳性表达率高于无脉管侵犯、淋巴结转移,且Ⅲ+Ⅳ期子宫内膜癌FOLR1、PSMA阳性表达率高Ⅰ+Ⅱ期者,有统计学差异(P<0.05);子宫内膜癌患者FIGO分期、脉管侵犯、淋巴结转移与FOLR1、PSMA阳性表达均呈正相关(P<0.05)。结论 PSMA、FOLR1可促进子宫内膜癌进展,其阳性表达率与患者FIGO分期、脉管侵犯、淋巴结转移密切相关。Objective To investigate the expression of folic acid receptor 1(FOLR1)and prostate-specific membrane antigen(PSMA)in different endometrial tissues.Methods From January 2021 to August 2023,98 paraffin-embedded specimens of endometrial cancer,30 specimens of atypical endometrial and 30 specimens of normal endometrial were collected from the Department of Pathology of the Fifth Affiliated Hospital of Zhengzhou University.FOLR1 and PSMA were detected by immunohistochemical staining.The positive expression of FOLR1 and PSMA in normal endometrial,atypical hyperplasia and cancer tissues was compared,and the correlation between the positive expression of FOLR1 and PSMA and clinicopathological features of endometrial cancer patients was analyzed.Results The positive expression rates of FOLR1 and PSMA in endometrial carcinoma were higher than those in normal endometrial with atypical hyperplasia(P<0.05).The positive expression rates of FOLR1 and PSMA in endometrium with atypical hyperplasia were higher than those in normal endometrium,but there was no statistical difference(P>0.05).There was no significant difference in FOLR1 and PSMA expression rate among different age,histological type and differentiation degree of endometrial carcinoma(P>0.05).The positive expression rates of FOLR1 and PSMA in endometrial carcinoma with vascular invasion and lymph node metastasis were higher than those without vascular invasion and lymph node metastasis,and the positive expression rates of FOLR1 and PSMA in endometrial carcinoma withⅢ+Ⅳstage were higher in endometrial carcinoma withⅠ+Ⅱstage,the difference was statistically significant(P<0.05).FIGO stage,vascular invasion and lymph node metastasis were positively correlated with FOLR1 and PSMA expression in endometrial carcinoma patients(P<0.05).Conclusion PSMA and FOLR1 can promote the progression of endometrial carcinoma,and their positive expression rates are closely related to FIGO stage,vascular invasion and lymph node metastasis.

关 键 词：子宫内膜癌 叶酸受体1 临床病理特征 前列腺特异性膜抗原 

分 类 号：R711.32[医药卫生—妇产科学]