内痔证候与用药规律文献研究  

Literature Study on Regularity of Syndrome and Medication of Internal Hemorrhoid

作　　者：潘世聪 李冰冰[2] 王孟欣 张一辉[3] 杨建华[3] 王晓鹏[3] 吴本升[3] 顾尽晖[3] 彭卫红 PAN Shi-cong;LI Bing-bing;WANG Meng-xin;ZHANG Yi-hui;YANG Jian-hua;WANG Xiaopeng;WU Ben-sheng;GU Jin-hui;PENG Wei-hong(Guizhou University of Traditional Chinese Medicine,Guiyang,Guizhou 550000;Nanjing University of Chinese Medicine,Nanjing,Jiangsu 210023;Suzhou Hospital of Traditional Chinese Medicine,Nanjing University of Chinese Medicine,Suzhou,Jiangsu 215009;Guizhou Provincial Southwest Institute of Anorectal Diseases,Guiyang,Guizhou 550001)

机构地区：[1]贵州中医药大学,贵州贵阳550000 [2]南京中医药大学,江苏南京210023 [3]南京中医药大学附属苏州市中医医院,江苏苏州215009 [4]贵州省西南肛肠杂病研究所,贵州贵阳550001

出　　处：《中国肛肠病杂志》2024年第11期34-38,共5页Chinese Journal of Coloproctology

基　　金：苏州市科技发展计划(民生科技)(SYSD2019239)。

摘　　要：目的:探讨内痔的证候证素分布规律及用药规律。方法:以Microsoft EXCEL建立数据库,运用SPSS 26.0软件分析内痔证候证素分布规律,应用中医传承辅助平台(V2.5)对内痔的组方规律进行描述性统计、关联规则分析。结果:共纳入文献60篇,证候类23篇,用药类58篇。湿热下注、脾虚气陷、风伤肠络为高频证候。内痔病位在脾、大肠,常见病性类证素依次为热、湿、气陷、风、瘀血。涉及药物124味,基于支持度为10%、15%、20%和置信度为70%的筛选标准下进行关联规则分析,分别得到药物间关联规则846、72、28条,核心用药分别为22、19、10个。结论:内痔病机为本虚标实,虚实夹杂,本虚为脾气虚、气血虚,标实主要是湿热下注、肠风热毒、血瘀,病位在脾与大肠,与肝、肾密切相关,热、湿、气陷、风、毒、气虚为其关键病理因素,重视其核心用药,针对症状灵活加减运用,为临床治疗提供参考和建议。Objective To investigate the regularity of syndrome and syndrome element distribution,and medication of internal hemorrhoids.Methods Database were established in Microsoft EXCEL,using SPSS 26.0software to analyze the distribution regularity of syndrome and syndrome element of internal hemorrhoids,and the traditional Chinese medicine inheritance platform(V2.5)was used to conduct descriptive statistics and association rule analysis of the medication regularity of internal hemorrhoids.Results A total of 60literatures were included,including 23literatures concerned with syndromes and 58 literatures with medication.Syndrome with high frequency include dampness-heat pouring down,spleen deficiency and qi collapse,and wind impairing intestinal collateral.Internal hemorrhoids are located in spleen and large intestine,and the common syndrome elements are heat,dampness,qi collapse,wind and blood stasis,involving total 124drugs.Association rules analysis was conducted based on the screening criteria of 10%,15%,20%support and 70%confidence,and 846,72,and 28association rules,and 22,19,and 10core drugs were obtained respectively.Conclusion The pathogenesis of internal hemorrhoids is primary deficiency in nature and excess in superficiality,deficiency-excess in complexity.Deficiency in nature includes spleen deficiency,deficiency of qi and blood.Excess in superficiality mainly consists of dampness-heat pouring down,intestinal wind-heat toxin and blood stasis.The disease location is in spleen and large intestine,34 Chin J Coloproctol 2024,Vol 44,No 11 which is closely related to liver and kidneys.Heat,dampness,qi collapse,wind,toxin and qi deficiency are the key pathological factors.The core drugs should be focused and flexibly used according to the symptoms,to provide references and suggestions for clinical treatment.

关 键 词：内痔 文献研究 数据挖掘 证候 证素 用药规律 

分 类 号：R266[医药卫生—中医外科学]