清脂化瘀膏对痰湿体质肥胖人群的干预效果  

Intervention effects of Qingzhi Huayu Ointment on obesity in individuals with phlegm-dampness constitution

作　　者：罗翠文 原嘉民 梁咏竹 郝艺照 叶晓红 屈子灵 黄鹂 成杰辉[1] 杨志敏 LUO Cui-wen;YUAN Jia-min;LIANG Yong-zhu;HAO Yi-zhao;YE Xiao-hong;QU Zi-ling;HUANG Li;CHENG Jie-hui;YANG Zhi-min(Healthcare Center,Zhuhai Hospital of Guangdong Provincial Hospital of Traditional Chinese Medicine,Zhuhai 519015,Guangdong,China;不详)

机构地区：[1]广东省中医院珠海医院治未病中心,广东珠海519015 [2]广州中医药大学第二附属医院、省部共建中医湿证国家重点实验室、广东省中医院治未病中心,广东广州510120

出　　处：《广东医学》2024年第12期1535-1539,共5页Guangdong Medical Journal

基　　金：省部共建中医湿证国家重点实验室项目(SZ2021ZZ31,SZ2021ZZ32);广东省中医药局科研项目(20211357);珠海市2017年引进高层次卫生人才(学科团队)专项。

摘　　要：目的探究清脂化瘀膏对痰湿体质肥胖人群的临床疗效和安全性。方法采用非随机对照的研究设计,以痰湿体质的肥胖人群作为研究对象,共纳入82例样本,其中对照组22例,予以饮食运动处方干预;观察A组30例,予以清脂化瘀膏口服;观察B组30例,在口服清脂化瘀膏基础上,加以饮食运动处方,共干预2个月,观察干预前后中医体质评分和肥胖相关指标的变化及试验过程中的安全性。结果(1)对照组脱落4例,共18例完成试验;观察A组脱落10例,共20例完成试验;观察B组脱落8例,共22例完成试验。(2)干预后,3组患者的痰湿体质分数均有明显下降(P<0.05),但组间比较差异无统计学意义(P>0.05)。(3)在肥胖相关指标中,3组患者的体重、腰围、BMI、肥胖度均较干预前明显下降(P<0.05),Inbody总分明显提升(P<0.05);其中在干预第2个月时,相比对照组的体重和腰围两个指标的下降曲线已趋于平缓时,两观察组仍继续保持良好的下降趋势(P<0.05);3组之中,观察B组的Inbody总分在干预的第1个月上升更快(P<0.05),观察B组干预前后的BMI以及肥胖度指标的降幅也更大(P<0.05)。(4)两观察组的心电图、肝肾功能等的安全性指标在干预后未出现明显的异常变化(P>0.05),且干预过程中未出现明显的不良反应。结论服用清脂化瘀膏对于改善痰湿体质和肥胖状态安全有效,口服清脂化瘀膏或同时配合科学的饮食和运动方案对肥胖人群减重、防治肥胖及相关并发症有积极意义。Objective To evaluate the clinical efficacy and safety of Qingzhi Huayu Ointment in individuals with obesity and phlegm-dampness constitution.Methods A non-randomized controlled study was conducted with 82 participants with phlegm-dampness obesity.The participants were divided into three groups:a control group(n=22)receiving dietary and exercise intervention;observation Group A(n=30)taking oral Qingzhi Huayu Ointment;and observation Group B(n=30)receiving both the ointment and dietary and exercise intervention for two months.Changes in TCM constitution scores and obesity-related indicators before and after intervention were observed,along with safety assessments throughout the study.Results Dropout rates were as follows:4 in the control group(18 completed),10 in observation Group A(20 completed),and 8 in observation Group B(22 completed).After intervention,all three groups showed a significant reduction in phlegm-dampness scores(P<0.05),though inter-group differences were not statistically significant(P>0.05).All three groups exhibited significant decreases in weight,waist circumference,BMI,and obesity degree,and an increase in Inbody scores(P<0.05).In the second month,both observation Groups maintained a greater downward trend in weight and waist circumference compared to the control group(P<0.05).Observation Group B demonstrated a more rapid increase in Inbody scores in the first month(P<0.05)and greater reductions in BMI and obesity degree by the end of the intervention(P<0.05).Safety indicators(ECG,liver,and renal function)showed no significant abnormalities post-intervention in the observation groups(P>0.05),and no adverse reactions were observed during the study.Conclusion Qingzhi Huayu Ointment is safe and effective for improving phlegm-dampness constitution and obesity.It may have added benefits in weight reduction and obesity-related health when combined with diet and exercise,suggesting a potential preventive role in obesity and its associated complications.

关 键 词：中医体质 肥胖 体质指数 

分 类 号：R25[医药卫生—中医内科学] R589.2[医药卫生—中医学]