中药抑制铁死亡抗动脉粥样硬化的研究进展  

Research progress on inhibiting ferroptosis in traditional Chinese medicine for atherosclerosis

作　　者：王萌媛 邱啸 邓志鹏 杨莹[1] WANG Mengyuan;QIU Xiao;DENG Zhipeng;YANG Ying(Shandong University of Traditional Chinese Medicine,Jinan 250355,China)

机构地区：[1]山东中医药大学,山东济南250355

出　　处：《药学研究》2024年第12期1220-1224,共5页Journal of Pharmaceutical Research

基　　金：山东省中医药科技项目(No.M-2022146)。

摘　　要：动脉粥样硬化是一种以血管内皮功能障碍、脂质沉积和慢性炎症为特征的复杂血管病变,是心血管疾病的主要病理基础。铁死亡是由于铁离子过量积累导致的脂质过氧化反应引起的细胞死亡方式。在动脉粥样硬化的发展过程中,铁死亡可加剧动脉粥样斑块中的脂质过氧化和炎症反应,显著影响斑块稳定性,增加心血管病的风险。近年来,中药通过调节铁稳态、抑制活性氧的生成、增强细胞的抗氧化反应等机制,抑制铁死亡的发生发展,为动脉粥样硬化的治疗提供了新的治疗思路。Atherosclerosis is a complex vascular disease characterized by endothelial dysfunction,lipid deposition,and chronic inflammation,and is the major pathological basis of cardiovascular disease.Ferroptosis is a mode of cell death caused by lipid peroxidation due to excessive accumulation of iron ions.During the development of atherosclerosis,ferroptosis significantly affects plaque stability and cardiovascular risk by exacerbating lipid peroxidation and inflammation in atheromatous plaques.In recent years,traditional Chinese medicine(TCM)has played an active role in the development of ferroptosis by regulating iron homeostasis,inhibiting reactive oxygen species generation and enhancing cellular antioxidant defense,providing new therapeutic strategy for the treatment of atherosclerosis.

关 键 词：中药 铁死亡 动脉粥样硬化 

分 类 号：R543.5[医药卫生—心血管疾病]