外周免疫在阿尔茨海默病发生发展中作用的研究进展  

Research advances on the role of peripheral immunity in the development and progression of Alzheimer disease

作　　者：崔灿 何谦益[1] 丁志方 岳悦(综述) 赵莘瑜(审校)[1] CUI Can;HE Qianyi;DING Zhifang(The First Affiliated Hospital of Zhengzhou University,Zhengzhou 450000,China)

机构地区：[1]郑州大学第一附属医院,河南郑州450000

出　　处：《中风与神经疾病杂志》2024年第12期1148-1152,共5页Journal of Apoplexy and Nervous Diseases

基　　金：河南省医学科技攻关计划联合共建项目(LHGJ20210301)。

摘　　要：阿尔茨海默病(AD)是以进行性认知功能障碍和行为损害为特征的中枢神经系统变性病变,逐渐成为本世纪负担最重的疾病之一。目前关于AD的发病机制现已较公认的学说是淀粉样蛋白级联假说,但近期的研究表明,免疫系统似乎在AD发病过程中起着举足轻重的作用,本文以现有文献中免疫系统与AD发生发展关系进行总结,着重探讨外周免疫在AD发生发展中的作用,具体阐述外周固有免疫和适应性免疫的作用,为此后AD在免疫方向的相关研究提供了新思路。Alzheimer disease(AD),a degenerative disease of the central nervous system characterized by progressive cognitive dysfunction and behavioral impairment,has gradually become one of the most burdensome diseases in this century.At present,the amyloid cascade hypothesis is a widely recognized theory on the pathogenesis of AD.However,recent studies have shown that the immune system can play an important role in the occurrence of AD.This article summarizes the relationship between the immune system and the development and progression of AD from the existing literature,with an emphasis on the role of peripheral immunity in both the innate and adaptive immune systems,aiming to provide novel ideas for future research on AD in the immunological direction.

关 键 词：阿尔茨海默病 外周免疫 发病机制 

分 类 号：R749.16[医药卫生—神经病学与精神病学]