Box-Behnken响应面法结合层次分析法优化萸仙茅炮制工艺  

Optimization of Processing Technology of Curculigo orchioides Gaertn.by Box-Behnken Response Surface Method Combined with Analytic Hierarchy Process

作　　者：徐国伟 王巍[1] 刘思翰 洪艺丹 张立强 鞠成国[1,2] XU Guowei;WANG Wei;LIU Sihan;HONG Yidan;ZHANG Liqiang;JU Chengguo(College of Pharmacy,Liaoning University of Traditional Chinese Medicine,Dalian 116600,China;Traditional Chinese Medicine Processing Technology Inheritance Base(Liaoning)of the State Administration of Traditional Chinese Medicine,Dalian 116600,China)

机构地区：[1]辽宁中医药大学药学院,辽宁大连116600 [2]国家中医药管理局中药炮制技术传承基地,辽宁大连116600

出　　处：《中国中医药信息杂志》2025年第1期134-139,共6页Chinese Journal of Information on Traditional Chinese Medicine

基　　金：国家中医药管理局中药炮制技术传承创新项目(GZY-KJS-2022-049)辽宁省教育厅高校基本科研项目(LJ222410162049)。

摘　　要：目的优选萸仙茅炮制工艺。方法在单因素试验基础上,以料液比、炒制时间和炒制温度为影响因素,以仙茅苷、苔黑酚葡萄糖苷、苔黑酚龙胆二糖苷含量及外观性状的综合评分为评价指标,利用Box-Behnken响应面法结合层次分析法优化萸仙茅最佳炮制工艺,并进行工艺验证。结果萸仙茅最佳炮制工艺为:取生仙茅饮片,加入等量吴茱萸汁拌匀,置密闭容器内,闷润至药汁被完全吸尽,于130℃炒制6min,取出,60℃干燥。每100kg仙茅用吴茱萸10kg。吴茱萸汁制法:取吴茱萸10kg,加12倍量水浸泡60min,煎煮50min,提取3次,合并滤液,浓缩至100kg。结论本研究优化所得萸仙茅的炮制工艺可行、稳定。Objective To optimize the processing technology of Curculigo orchioides Gaertn.Methods On the basis of single factor experiment,the ratio of material to liquid,frying temperature and frying time were taken as the influencing factors,and the comprehensive scores of appearance traits,curculigoside,orcinol glucoside and orcinol gentiobioside were taken as the evaluation indexes.The optimal processing technology was optimized by Box-Behnken response surface method combined with analytic hierarchy process,and the process verification was carried out.Results The optimal process was as follows:the raw C.orchioides pieces were mixed with the same amount of Evodia rutaecarpa juice,placed in a closed container,moistened until the juice was completely absorbed,stir-fried at 130℃ for 6 min,taken out and dried at 60℃.For each 100 kg of Curculigo,10 kg of Evodia rutaecarpa was used.Evodia rutaecarpa juice preparation method:10 kg of Evodia rutaecarpa was soaked in 12 times the amount of water for 60 min,decocted for 50 min,extracted for 3 times,combined with the filtrate,and concentrated to 100 kg to obtain Evodia rutaecarpa juice.Conclusion The optimal processing technology of Curculigo orchioides Gaertn.is stable and feasible.

关 键 词：萸仙茅 Box-Behnken响应面法 层次分析法 炮制工艺 

分 类 号：R283.3[医药卫生—中药学]