慢性阻塞性肺疾病患者ABO血型分布及α1-抗胰蛋白酶含量的研究  

STUDY ON THE DISTRIBUTION OF ABO BLOOD GROUPS AND THE CONTENT OF α1-ANTITRYPSIN(α1-AT) IN PATIENTS WITH CHRONIC OBSTRUCTIVE PULMONARY DISEASE (COPD)

作　　者：霍建民[1] 于世寰[1] 徐子平[1] 杨光[2] 

机构地区：[1]哈尔滨医科大学第一临床医学院呼吸内科,哈尔滨15000 [2]黑龙江省电力医院

出　　处：《中国现代医学杂志》2002年第22期3-5,共3页China Journal of Modern Medicine

摘　　要：目的 :探讨我国汉族COPD患者ABO血型分布α1-AT含量 ,以及ABO血型与COPD、α1-AT含量间的关系。方法 :采用常规玻片法测定 6 11名汉族健康者及 2 0 0名COPD患者的ABO血型 ;单相免疫扩散法测定了其中 180名COPD患者的α1-AT含量。用Bernstein法及其较正公式计算ABO血型基因频率 ,woolf统计法计算相对发病率。结果 :健康者与COPD组间ABO血型构成特征均为B >O >A >AB ,两组的基因频率分别为P =0 .1912 ;0 .1886 q =0 .2 371;0 .2 6 99r =0 .5 717;0 .5 4 15 ;两组ABO血型分布均符合Hardy -Wemberg平衡法则。A/O和B/O的相对发病率分别为 1.0 993和 1.2 897(P >0 .0 5 ) ;A、B、O、AB四种血型COPD的相对危险率分别为 0 .95 5 7、1.2 14 9、0 .8314、1.0 4 13(P均 >0 .0 5 ) ;不同血型的COPD患者的α1-AT含量无差异 (P >0 .0 5 )。结论 :本组COPD患者中ABO血型抗原与COPD的发病无明显关联 ,这与国外某些学者报道的COPD患者以A型血为多的结果不同 ,其原因可能为 :种族差异 ;样本量少所致。本组COPD不同血型间的α1-AT含量无差异。因此 ,在我国ABO抗原与COPD发病及ABO血型与α1-AT含量的确切关系有待进一步探讨。Objective:To study the distribution of ABO blood groups, the content of α1 -AT and the relation among ABO blood groups, COPD and the content of α1-AT in patients with COPD.Methods: The ABO blood groups from 611 normal persons in Chinese Han race and 200 patients with COPD were determined by routine slide method; the content of α1-AT in 180 of all the patients with COPD were determined by single immunodiffusion test .Gene frequency of ABO blood groups was counted by Bernstein's method and its rectified formula; Relative morbidity was calculated by Woolf's statistics.Results:Constitution feature of ABO blood groups is B>O>A>AB in both of the normal group and COPD group. The gene frequency of the two groups are P =0.1912; 0.1886, Q=0.2371; 0.2699, r=0.5717; 0.5415; The distribution of ABO blood groups of the two groups are in accord with Hardy-Weinberg's balance-law. The relative morbidity of A/O and A/B is respectively 1.0993 and 1.2897 ( P >0.05), relative risk rate of patients with COPD with different blood types (A? B? O? AB) is respectively 0.9557?1.2149? 0.8314? 1.0413 ( P >0.05). There is no difference in the content of α1-AT of the patients with COPD with different blood types.Conclusions:There is no significant relation between ABO blood groups and morbidity of the patients with COPD, which is different from the result that the patients of types A is more than the others reported by some foreign scholar .Why we got different result may be due to the difference of nationality and deficiency of specimen. There is no difference among the content of α1-AT of the patients of different blood type with COPD. Therefore, the accurate relations between different antigens and morbidity, the contents of α1-AT and ABO blood type will be further studied in our country.

关 键 词：慢性阻塞性肺疾病 ABO血型 COPD Α1-AT 单相免疫扩散法 

分 类 号：R563[医药卫生—呼吸系统]