大鼠尾核内注射多巴胺受体激动剂、拮抗剂对血压和心率的影响  

EFFECT OF CAUDATE NUCLEUS INJECTION OF DOPAMINE RECEPTOR AGONIST/ANTAGONIST ON THE BLOOD PRESSURE AND HEART RATE IN RATS

作　　者：张艳霞[1] 闫瑞臻[1] 刘文彦[1] 史为清[1] 王曙光[1] 

机构地区：[1]山东济宁医学院生理教研室,272013

出　　处：《中国现代医学杂志》2002年第22期8-10,共3页China Journal of Modern Medicine

摘　　要：目的 :探讨尾核内多巴胺活动对心血管功能的影响 ,方法 :给乌拉坦麻醉大鼠尾核内微量注射多巴胺受体激动剂、拮抗剂 ,观察其动脉血压和心率的变化。结果 :一侧尾核内微量注射多巴胺或多巴胺受体激动剂阿朴吗啡均引起大鼠动脉血压、心率的显著增加。注射多巴胺受体拮抗剂氟哌啶醇则引起血压和心率的降低。结论 :大鼠尾核可通过多巴胺受体起作用参与心血管活动的调控。Objective:To study the effect of dopamin receptor agonist and antagonise in caudate nucleus on the cardiovascular function. Methods:Microinjected agonist or antagonist of dopamine receptors into caudate nucleus of anesthetized rats then observed the changes of arterial blood pressure and heart rate.Results:A microinjection of dopamine or apomorphinc, a dopamine receptor agonist, resulted in an evident increase in blood pressure and heart rate, but haloperidol (halo) can reduced them mildly.Conclusion:The results demonstrate that caudate nucleus may take part in the cardiovascular regulation through DA receptors.

关 键 词：尾核 多巴胺受体 血压 心率 动物实验 

分 类 号：R331[医药卫生—人体生理学]