乙型肝炎表面抗原阳性母亲的新生儿乙肝基因疫苗免疫效果的前瞻性研究  

A cohort study on the immune effect of hepatitis B gene vaccine in HBV infection women's neonates

作　　者：王德全[1] 陈学旻[1] 

机构地区：[1]广东药学院流行病学教研室,广东广州510224

出　　处：《疾病控制杂志》2002年第4期294-296,共3页Chinese Journal of Disease Control and Prevention

摘　　要：目的　探讨乙型肝炎病毒 (HBV)感染的母亲对新生儿乙型肝炎 (简称乙肝 )基因疫苗免疫接种效果的影响。方法　按母亲是否有 HBV感染 ,将新生儿分为暴露组和非暴露组各 76名 ,追踪观察两组新生儿接种乙肝基因疫苗后 1、2和 7个月龄时的免疫效果 ,采用酶联免疫吸附试验(EL ISA)、聚合酶链反应 (PCR)法和测定吞噬细胞吞噬功能的化学发光法进行血液检测。结果　在两组新生儿系列血清中均未检出 HBV DNA和血清 HBV感染标志物 ,暴露组乙肝疫苗无应答率为 19.74 % (15 /76 ) ,而非暴露组乙肝疫苗免疫无应答率为 6 .5 8% (5 /76 ) ,两组比较 ,差异具有显著性 (χ2 =2 1.5 6 ,P <0 .0 1)。疫苗接种后 2个月和 7个月时 ,暴露组外周血吞噬细胞的吞噬功能明显下降。结论　母亲感染 HBV后对新生儿的吞噬细胞活性和抗 -Objective To explore effect of maternal HBV infection on neonatal immunization with hepatitis B gene vaccine. Methods Prospective study was conducted in evaluation of immune effects with ELISA?PCR and the cellular phagocytosis was examined by luminolenhanced chemiluminescnce assay. Results Hepatitis B virus nucleotide (HBV DNA) and serological infectious markers were not found in neonatal series serum. The immunization protective rates in exposure and noexposure group were 80.3% (61/76) and 93.4% (71/76), respectively. After hepatitis B vaccinated, the cellular phagocytosis decreased obviously in 2nd and 7th month in exposed group. Conclusions Maternal HBV infection state at parturition might make some effects on neonatal anti HBs positive transformation.

关 键 词：乙型肝炎表面抗原 阳性 新生儿 基因疫苗 免疫效果 

分 类 号：R186[医药卫生—流行病学] R512.62[医药卫生—公共卫生与预防医学]