模拟失重对新西兰兔股静脉压力-容积关系的影响  

Effects of Simulated Weightlessness on Pressure-volume Relationships of Femoral Vein of New Zealand Rabbits.

作　　者：岳勇[1] 姚永杰[1] 谢小萍[1] 王冰[1] 朱庆生[2] 吴兴裕 

机构地区：[1]第四军医大学航空航天医学系,陕西西安710032 [2]第四军医大学西京医院骨科,陕西西安710032

出　　处：《航天医学与医学工程》2002年第6期410-414,共5页Space Medicine & Medical Engineering

基　　金：国家自然科学基金 (3 0 0 0 0 197)

摘　　要：目的观察模拟失重对兔股静脉压力 -容积关系的影响及静脉壁显微结构的变化。方法采用头低位 ( - 2 0°)倾斜的方法作为模拟失重家兔模型。 2 4只雄性健康新西兰兔 ,随机分为对照组、模拟失重 2 1d组和模拟失重 1 0d组 ,每组 8只。进行股静脉的压力 -容积 (P V)关系测试 ,并观察血管壁的显微结构。结果模拟失重后股静脉P V曲线向容积变化比增大的方向移动 ,模拟失重 2 1d组较 1 0d组移动更明显。分别于加、卸载测试时拟合出的模拟失重 2 1d组P V二次抛物线方程式系数B1 、B2 值均显著高于对照组及模拟失重 1 0d组 (P <0 .0 1 ) ,模拟失重 1 0d组的B1、B2值和对照组相比有增加的趋势。组织学观察表明 ,模拟失重组股静脉内皮细胞呈立方或矮柱状并有细胞脱落 ,平滑肌层变薄等变化。结论模拟失重后股静脉顺应性增加 ,2 1d组较 1 0d组增加明显 。Objective To observe the changes of pressure volume relationships of rabbit femoral veins and their structural changes caused by simulated weightlessness. Method Head Down Tilt(HDT) -20° rabbit model was used to simulate weightlessness.Twenty four healthy male New Zealand Rabbits were randomly divided into 21 d HDT group,10 d HDT group and control group, (8 in each group). Pressure volume(P V) relationship of rabbits femoral veins was measured and the microstructure of the veins was observed. Result The femoral vein P V relationship curves of HDT groups showed a larger volume change ratio than that of control group. This change was that 21 d HDT group was even more obvious than that of HDT 10 d group. B1 and B2 in quadratic equations of 21 d HDT group were significantly higher than the values of both 10 d HDT group and control group during expansion (inflow) and collapse (outflow) (P<0.01). The result of histological examination showed that the contents and structure of femoral vein wall of HDT rabbits changed significantly. Endothelial cells of femoral vein became short and columnar or cubic, some of which fell off. Smooth muscle layer became thinner. Conclusion Femoral venous compliance increased after weightlessness simulation and the femoral venous compliance in 21d HDT rabbits increased more obviously than that in 10 d HDT rabbits. The structure of femoral vein wall had changed obviously.

关 键 词：模拟失重 新西兰兔 股静脉 压力-容积关系 顺应性 显微结构 

分 类 号：R852.22[医药卫生—航空、航天与航海医学]