系数倍率法测定复方甲硝唑含漱剂中甲硝唑的含量  

Determination of metronidazole in polypharmacon metronidazole gargle by signal multiplier spectophotometry

作　　者：于莲[1] 马晟利[2] 苏瑾[1] 郭守志[3] 

机构地区：[1]佳木斯大学化学与药学院,佳木斯154007 [2]佳木斯大学第二附属医院,佳木斯154003 [3]佳木斯中药厂,佳木斯154007

出　　处：《黑龙江医药科学》2002年第6期15-16,共2页Heilongjiang Medicine and Pharmacy

摘　　要：目的：测定复方甲硝唑含漱剂中甲硝唑的含量。方法：系数倍率法。结果：经回归得回归方程为：y=0.04x-0.0118，r=0.9995，线性范围为8-16μg/ml，平均回收率为100.29％，RSD为1.78％。结论：系数倍率法可消除附加剂的干扰，直接测定复方甲硝唑含漱剂中甲硝唑的含量，方便、实用、灵敏度和准确度好，适合于医院该制剂的质量监控。Objective: To determine the content of metronidazole of polypharmacon metronidazole(INN) gargle. Method: signal multiplier spectophotometry was used. Result: The liner regression equation was y=0.04x-0.0118, r=0.9995, whose liner ranger was 8~16g/ml. The average recovery rates was 100.29%, RSD=1.78%. Conclusion: The result illustrates that the accuracy and precision is better and it fits the quantitatively study of this gargle in hospital.

关 键 词：系数倍率法 复方甲硝唑含漱剂 甲硝唑 含量测定 质量控制 医院制剂 

分 类 号：R927.2[医药卫生—药学] R978.