比色法测定奥沙普嗪的含量  

Determination of Oxaprozin by colorimetric method

作　　者：高金波[1] 李国清[2] 张楠楠[1] 南刚 

机构地区：[1]佳木斯大学化学与药学院 [2]哈尔滨学院化学系

出　　处：《黑龙江医药科学》2002年第6期28-29,共2页Heilongjiang Medicine and Pharmacy

摘　　要：目的:用比色法测定奥沙普嗪的含量。方法:把奥沙普嗪的羧基转变为酰氯,并同羟胺结合而得一种氧肟酸,再使氧肟酸同钒在酸性介质中结合生成一种黄色的化合物。该黄色化合物在波长为387nm处有最大吸收,而样品辅料经显色反应在此无吸收,故选择387nm为测定波长。结果:回收率为99.25%±0.8%,RSD<1.0%。Objection: To determinate oxaprozin by colorimetric method. Method: The oxatylamong oxaprozin was turned into acyl chloride and then combined with oxyammonia. Oxidooximide acid was combined with vanadium in acid media to produce a yellow compound. The measurement wavelength at 387nm was selected. Results: RE 99.25%±0.8%.RSD<1.0%.

关 键 词：奥沙普嗪 比色法 含量测定 氧肟酸 

分 类 号：R971.1[医药卫生—药品] R927.[医药卫生—药学]