α-干扰素治疗流行性乙型脑炎80例  

80 Cases of Epidemic Encephalitis B Treated with Interferon-α

作　　者：李志新[1] 艾志龙[1] 许春仿[1] 

机构地区：[1]湖北省仙桃市第一人民医院儿科,433000

出　　处：《医药导报》2002年第12期768-769,共2页Herald of Medicine

摘　　要：目的 :观察α 干扰素治疗流行性乙型脑炎的疗效。方法 :160例流行性乙型脑炎患者随机分为治疗组、对照组各 80例。治疗组除综合治疗 ,包括药物 (人工冬眠 )、物理降温 (冰枕 )、止惊、脱水、防治感染外 ,给予α 干扰素 10 0万U ,im ,qd ,治疗至体温正常后停药 ,α 干扰素治疗 3～ 7d ,平均 5 .7d ;对照组仅给予综合治疗。观察两组症状、体征、后遗症、病死率的变化。结果 :治疗组昏迷发生率明显低于对照组 (P <0 .0 5 ) ;在退热时间以及嗜睡、颈强的改善等方面优于对照组 ;治疗组病死率 (5 .0 % )较对照组病死率 (17.5 % )明显下降 (P <0 .0 5 )。结论 :α 干扰素对流行性乙型脑炎有较好疗效。Objective:To survey the therapeutic effectiveness of interferon α in the treatment of epidemic encephalitis B(EEB). Methods:160 cases of EEB were randomly divided into two equal groups: the treatment group 80 cases and control group (80 cases). In addition to the combined treatment including drugs (artificial hibernation),hypothermy with physical measure(ice pillow), antispasm, dehydration, prevention of infection etc. The patients of the treatment group were given each interferon α at a dose of 1×10 6 U i.m., q.d.. The medication was discontinued after the lady temperature had become normal. The course of interferon α treatment lasted 3-7 days, with an average of 5-7 days. Patients of the control group received the combined treatment only. Symptoms, signs, sequelae and case fatality rate were noted. Results:The incidence of come was significantly lower in the treatment group than in the control group ( P <0.05). Besides the results with respect to the time of fever abatement, improvement in lethargy and neck rigidity etc., were also evidently better in the treatment group than in the control group. Case fatality rate of the treatment group (5.0%) was significautly lower than that of the control group(17.5%) ( P <0.05). Conclusion:Interferon α was found to have a fairly good therapeutic effect in the treatment epidemic encephalitis B.

关 键 词：Α-干扰素 治疗 流行性乙型脑炎 疗效 作用机制 

分 类 号：R512.32[医药卫生—内科学] R979[医药卫生—临床医学]