蒿属花粉过敏变应性鼻炎与HL-ADQA1、DQB1基因的关系  

Association of hypersensitivity to wormwood pollen in patients with allergic rhinitis with HLA alleles polymorphism

作　　者：邢志敏[1] 于德林[1] 安淑兰[1] 

机构地区：[1]北京大学人民医院耳鼻咽喉科,北京100034

出　　处：《临床耳鼻咽喉科杂志》2002年第12期678-680,共3页Journal of Clinical Otorhinolaryngology

摘　　要：目的 :研究北京地区蒿属花粉过敏变应性鼻炎 (AR)患者HLA DQA1、DQB1基因与蒿属花粉过敏易感性的关系。方法 :用聚合酶链反应 序列特异性引物技术 (PCR SSP) ,检测HLA DQA1、DQB1基因型在 4 1例以蒿属花粉过敏为主的AR患者及 4 1例对照组间的分布 ,并统计分析了二者间的分布差异。结果 :4 1例变应性鼻炎患者DQA1 0 2 0 1、DQB1 0 6 0 2基因频率 (2 4 .39%、4 .88% )明显低于对照者 (46 .34%、2 6 .83% ) ,而DQA1 0 30 2基因频率 (5 8.5 4 % )明显高于对照者 (14 .6 3% ) ,具有统计学意义。结论 :提示HLA DQA1 0 2 0 1、DQB1 0 6 0 2基因可能是AR发病的抗性基因 ,而DQA1 0 30 2可能是AR发病的易感性基因。Objective:Our purpose was to determine whether alleles at one or more HLA loci are associated with hypersensitivity to wormwood pollen in patients with allergic rhinitis.Method: By using PCR SSP(sequence specific primer polymerase chain reaction),we tested the frequency distribution of HLA DQA1?DQB alleles in 41 patients with allergic rhinitis(AR) and 41 healthy controls from Beijing.Result: The frequency of HLA DQA1*0201?DQB1*0602 was lower in AR than in controls( 24.39 %? 4.88 % vs 46.34 %? 26.83 %),and the frequency of DQA1*0302 was increased among patients( 58.54 % vs 14.63 %).Conclusion: HLA DQA1*0201?DQB1*0602 lleles might confer protection against AR, and DQA1*0302 may be a susceptibility factor for hypersensitivity to wormwood pollen.

关 键 词：变应性鼻炎 HLA基因 聚合酶链反应 

分 类 号：R765.21[医药卫生—耳鼻咽喉科]