血管内皮祖细胞的研究进展  

Advances in the research of endothelial progenitor cells

作　　者：杨晨[1] 杨仁池[1] 韩忠朝[1] 

机构地区：[1]中国医学科学院中国协和医科大学血液学研究所实验血液学国家重点实验室,天津300020

出　　处：《基础医学与临床》2002年第5期391-396,共6页Basic and Clinical Medicine

基　　金：国家攀登计划 (95 专 10 ) ;国家杰出青年科学基金 (3972 5 0 14 )

摘　　要：在胚胎发育过程中 ,血管系统的建立始于两种方式 :血管发生和血管新生。传统理论认为血管新生即是出生后血管发生的代名词。然而 ,近年来发现循环中存在骨髓来源的血管内皮祖细胞 ,并与出生后血管发生密切相关 ,具有重要的生理、病理意义。这不仅拓展了干细胞的研究 ,也为缺血性疾病和肿瘤的治疗提供了新策略。本文简述了血管内皮祖细胞的来源、细胞表面标志、生物学特性。Vasculogenesis and angiogenesis are two types of neovascularization in the embryo development. It has long been believed that postnatal neovasculogenesis is synonymous with angiogenesis. However, bone marrow derived endothelial progenitor cells have been isolated from peripheral circulation and shown to be incorporated into foci of physiological and pathological neovascularization, consistent with postnatal vasculogenesis in recent years. The finding has not only extended the field of stem cells research, but also offered new strategies for the treatment of ischemic vascular diseases and tumors. In this review, we summarized the origin, cell surface markers, biological characteristics, physiological and pathological significance and clinical application perspective of endothelial progenitor cells.

关 键 词：血管内皮祖细胞 出生后血管发生 治疗性血管发生 血管新生 EPC 细胞表面标记 生物学特性 

分 类 号：R329[医药卫生—人体解剖和组织胚胎学]