门控^(99)Tc^m-MIBI/^(18)F-FDG双核素同时采集显像评价左心室功能  

Evaluation of left ventricular function by~ (99)Tc^m-MIBI/~ (18)F-FDG gated myocardial tomography with dual isotope simultaneous acquisition

作　　者：沈锐[1] 刘秀杰[1] 史蓉芳[1] 田月琴[1] 魏红星[1] 郭风[1] 何作祥[1] 高润霖[2] 

机构地区：[1]中国医学科学院中国协和医科大学阜外心血管病医院核医学科,北京100037 [2]中国医学科学院中国协和医科大学阜外心血管病医院心内科,北京100037

出　　处：《中华核医学杂志》2002年第5期263-265,共3页Chinese Journal of Nuclear Medicine

摘　　要：目的　探讨门控99Tcm 甲氧基异丁基异腈 (MIBI) /18F 脱氧葡萄糖 (FDG)双核素同时采集 (DISA)显像评价左心室功能的临床价值。方法　 77例冠心病患者行门控DISA ,其中 5 3例行X线左心室造影 (LVG) ,分别比较LVG心室射血分数 (EF)值和DISA法门控99Tcm MIBI和18F FDG同时显像所得EF值。局部室壁运动行Kappa值比较。结果　门控99Tcm MIBI和门控18F FDG显像所得EF值间相关性高 (r =0 .90 ,P <0 0 0 1)。两者与LVGEF值相关性均高 (r分别为 0 .86和 0 .85 ,P均 <0 0 0 1)。门控99Tcm MIBI和18F FDG显像与LVG比较Kappa值分别为 0 .765和 0 .742。结论　门控99Tcm MIBI/18F FDGDISA可同时了解左室心肌灌注、代谢及功能 ,提供左心室功能的重要信息 ,有重要的临床价值。Objective To evaluate the accuracy of left ventricular ejection fraction (LVEF) and regional wall motion measured by gated SPECT with dual isotope[~ 99Tc^m-methoxyisobutylisonitrile (MIBI) and ~ 18F-fluorodeoxyglucose (FDG)] simultaneous acquisition (DISA). Methods Seventy-seven patients with coronary artery disease (CAD) underwent ~ 99Tc^m-MIBI/~ 18F-FDG myocardial gated SPECT with DISA using a dual-head SPECT system equipped with ultra-high-energy collimators. LVEF obtained by gated SPECT was measured using a commercially available software. Contrast left ventriculography (LVG) was performed as well in 53 patients separately from myocardial SPECT within (6.0±8.6) d apart from each other. Results LVEF was (38.3±13.6)% obtained by~ 99Tc^m-MIBI, (39.5±13.5)% by ~ 18F-FDG, respectively. Correlation between LVEF measured by ~ 99Tc^m-MIBI and ~ 18F-FDG gated SPECT was excellent (r=0.90,P<0.001). Both LVEFs determined by ~ 99Tc^m-MIBI (r=0.86,P<0.001) and ~ 18F-FDG (r=0.85, P<0.001) gated SPECT correlated well to that determined by contrast ventriculography. Correlation of regional wall motion measured by LVG with that come from gated SPECT of both isotopes was good with the Kappa value being 0.765 (~ 99Tc^m-MIBI) and 0.742 (~ 18F-FDG), respectively. Conclusions Left ventricular global and regional function can be accurately measured using ~ 99Tc^m-MIBI/~ 18F-FDG myocardial gated SPECT with DISA. It is thus feasible to obtain the information about left ventricular myocardial perfusion, metabolism and function simultaneously.

关 键 词：左心室功能 门控血池显像 脱氧葡萄糖 MIBI 心脏功能试验 冠心病 

分 类 号：R817[医药卫生—影像医学与核医学]