极端酶的研究进展  

Research Development on Extreme Enzymes

作　　者：翁樑[1] 冯雁[1] 

机构地区：[1]吉林大学分子酶学工程实验室,长春130023

出　　处：《生物化学与生物物理进展》2002年第6期847-850,共4页Progress In Biochemistry and Biophysics

摘　　要：极端酶具有超常的生物学稳定性 ,能够在极端温度、pH、压力和离子强度下表现出生物学活性 ,因此极端酶为生物催化和生物转化提供了良机 .新的极端物种的发现、基因组序列的确定及基因工程技术的应用 ,加快了发现和制备新酶的进程 .蛋白质工程和定向进化技术进一步改善酶的活性和特异性 ,促进了极端酶的工业应用 .对极端酶的研究加深了人们对酶稳定性机制的理解 。Extreme enzymes have super biological stability. They demonstrate biological activity at extreme temperatures, pH, pressure and ionic intensities. Thus, extreme enzymes provide good opportunities for biological catalysis and transformation. The discovery of the new extreme species, the confirmation of the genome sequence and the application of gene engineering technology have expedited the discovery and preparation of the new enzymes. Protein engineering and directed evolution further alter the enzymatic activity and peculiarity of the extreme enzymes, which fosters the industrial application of the extreme enzymes. Research on extreme enzymes increases comprehension of the mechanism of enzymatic stability and enriches the theory of molecular evolution.

关 键 词：极端酶 研究进展 异源表达 生物催化 

分 类 号：Q814[生物学—生物工程] Q55