低氧诱导因子-1的转录活性调控及其信号传导  

Regulation and Signaling Pathway of Hypoxia-inducible Factor-1 Activation

作　　者：张鹏华[1] 陈兰英[1] 

机构地区：[1]中国协和医科大学中国医学科学院阜外心血管病医院心血管病研究所,北京100037

出　　处：《生物化学与生物物理进展》2002年第6期863-867,共5页Progress In Biochemistry and Biophysics

基　　金：国家重点基础研究发展规划资助项目 (973 ) (G2 0 0 0 0 5 690 8)~~

摘　　要：低氧诱导因子 1(hypoxia induciblefactor 1,HIF 1)是氧平衡调控相关的转录因子 .依赖HIF 1的基因表达调控系统广泛影响葡萄糖代谢、细胞增殖、凋亡和血管发生 ,与机体低氧适应、胚胎发育、各种缺血性疾病及肿瘤相关 .HIF 1自身活性调节是低氧应答基因表达调控的中心环节 .调控主要发生在源于Ras的两条信号途径 :Ras/Raf/MEK介导的HIF 1反式激活功能调控 ,PI(3)K/Akt依赖的HIF 1alpha蛋白稳定性调控 .这两个信号传导途径分别独立又协调地调控着HIFHIF 1 (hypoxia inducible factor 1), a transcription factor involved in homeostasis of oxygen concentration, upregulates gene expression in processes of glycolysis, cell proliferation and apoptosis, angiogenesis, and contributes to mammalian organism hypoxia adaptation, embryo development, various ischemic diseases and tumors. The regulation of HIF 1 activity is the focus of hypoxia responsive genes expression. The regulation occurs dominantly at the two divergent signaling pathways rooting from Ras, transactivation mediated by Ras/Raf/MEK pathway and PI(3)K/Akt dependent stabilization of HIF 1alpha protein, cooperatively but independently regulates the activity of HIF.

关 键 词：低氧诱导因子-1 转录活性 调控 信号传导 

分 类 号：Q257[生物学—细胞生物学] Q75