不同剂量砷对大鼠大脑皮层乙酰胆碱脂酶活性的影响  

Effect of diffarence dose arsenite on AChE of cerebral cortex in rat

作　　者：毕伟东[1] 王成艳[2] 靳立巾[1] 熊杰[1] 李积胜[1] 

机构地区：[1]武警医学院神经生物学研究室,天津300162 [2]武警医学院训练部,天津300162

出　　处：《微量元素与健康研究》2002年第4期12-13,29,共3页Studies of Trace Elements and Health

摘　　要：目的 :探讨不同剂量砷对大鼠大脑皮层乙酰胆碱脂酶 (ACh E)的影响。方法 :以剂量递增法建立染砷大鼠动物模型。1 2周后 ,测定不同剂量砷对大鼠大脑皮层乙酰胆碱脂酶 (ACh E)的影响。结果 :不同剂量染砷组间大鼠大脑皮层乙酰胆碱脂酶 (ACh E)活性有显著性差别 (P<0 .0 5 )。随剂增加 ACh E值降低 (P<0 .0 5 ) ,呈剂量—效应关系。低剂量组与正常对照组相比 ,乙酰胆碱脂酶活性无显著性差别 (P>0 .0 5 )。结论 :随染砷剂量增加 ,大鼠大脑皮层 ACh E活性降低 ,呈剂量—效应关系。Objective:To study the effect of difference dose Arsenite on acetyicholinease of cerebral cortex.Methord:Animal model were created by means of increasing dose,After 12 week,the activity of AChE in cerebral cortex of four group rats were measured.Results:AChE activity of cerebral cortex in rat was significantly different in the differert dose groups (P<0 05).With the rise of dose,AChE level in cerebral cortex was markedly lower (P<0 05).and was in a dose-effect manner.AChE activity was not significantly different between low-does and high-dose group(P>0 05)?Conclusion:Level of AChE of cerebral cortex could be affected by Arsenity.The change was in a dose-effect manner.

关 键 词：砷 大鼠 大脑皮层 乙酰胆碱脂酶 神经毒性 

分 类 号：R995[医药卫生—毒理学]