乙型肝炎患者1～15年的追踪观察及预后分析  

ONE TO FIFTEEN YEARS′ FOLLOW-UP AND PROGNOSIS ANALYSIS OF PATIENTS WITH HEPATITIS B

作　　者：王志明[1] 陈伟华[1] 李明山[1] 田琦琦[1] 郭素萍[1] 谭复明[1] 刘丽宁[1] 

机构地区：[1]解放军第260医院

出　　处：《解放军医学杂志》2002年第11期962-964,共3页Medical Journal of Chinese People's Liberation Army

摘　　要：对 18 2例经组织学确诊的乙型肝炎患者进行 1～ 15年的随访 ,每年采血检测肝功能、病毒学指标及HBVDNA定量 ,了解乙型肝炎患者的远期临床及HBVM变化。显示 ,累计死亡 14例 ,转为肝硬化 15例 ,肝癌 6例 ,累计HBsAg阴转率为 13 6 %、HBeAg阴转率为 87 9% ,6 0岁以后HBsAg阳性率明显下降。提示慢乙肝患者血清HBVM有自发清除和不易清除双向趋势 ,肝组织损害迁延不愈 。The purpose of this study was to understand the long term changes in clinical picture and the markers of hepatitis B virus (HBV) in patients with hepatitis B, and to provide an objective evalution and a beneficial countermeasure. Altogether 182 patients with hepatitis B diagonsed by histopathological assay had been followed up for 1 to 15 years.The serum samples were collected and tested for liver fonction, markers of HBV and HBV DNA level once every year. The results showed that of the 182 patients, 14 died, 15 developed liver cirrhosis, and 6 developed liver cancer. HBsAg and HBeAg seroconversion happened in 13 6% and 87 9% of the patients, respectively. The percentage of positive HBsAg in patients older than 60 decreased at a great rate. Our conclusion in the markers of HBV in patients with chronic hepatitis B could dissapear automatically or, on the contrary could hardly dissapear, resulting persistentce of liver damage. The patients with liver cirrhosis could live for a iong time if they took good care of their health properly.

关 键 词：乙型肝炎 肝组织学 乙型肝炎病毒 肝功能 病毒学 HBV DNA 

分 类 号：R512.62[医药卫生—内科学]