甲磺酸多沙唑嗪治疗原发性高血压临床研究  

Clinical Experience in Treatment of Mild to Moderate Essential Hypertension With Doxazosin

作　　者：游凯[1] 陈国伟[2] 林纯莹[3] 黎莉[4] 王克平 沃金喜 陈端霞[1] 张原力[1] 麦炜颐[2] 林展翼[3] 张梅[4] 曹兆华 刘同涛[4] 高洁 蔡尚郎[6] 

机构地区：[1]中国医学科学院中国协和医科大学北京协和医院心内科,北京市100730 [2]中山大学附属第一医院心内科 [3]广东省心血管病研究所心内科 [4]山东大学齐鲁医院心内科 [5]山东省人民医院心内科 [6]青岛医学院附属医院心内科

出　　处：《中国循环杂志》2002年第5期354-356,共3页Chinese Circulation Journal

摘　　要：目的 :评价甲磺酸多沙唑嗪片 (络欣平 )对轻、中度原发性高血压的疗效和近期安全性。　　方法 :对 344例患者进行随机、双盲和前瞻性对照研究 ,随机将患者分为口服甲磺酸多沙唑嗪组 (治疗组 96例 ) ,口服盐酸特拉唑嗪组 (对照组 97例 ) ;其他患者口服甲磺酸多沙唑嗪 (开放组 1 51例 ) ,所有患者均服药 4周。　　结果 :各组用药后血压均明显下降 ,有非常显著性差异 (P <0 0 1 ) ,治疗组、对照组和开放组降压总有效率分别为 91 6 6 %、 94 85%和 90 0 0 %。治疗组用药后血脂改变突出。各组肝肾功能和心电图检查均无明显异常改变。治疗组头晕、心悸等不良反应发生率为 1 4 5% ,与对照组无差异。　　结论 :国产甲磺酸多沙唑嗪片降压效果明显且稳定 ,对调节血脂有益 ,患者依从性好。Objective:To evaluate the efficacy and safety of doxazosin for mild to moderate essential hypertension Methods:A prospective,randomized,double blind study was carried out in 344 patients with hypertension The patients were randomly given doxazosin(treatment group,n=96) or terazosin(control group,n=97)for four weeks The other 151 patients were given doxazosin(open group)for four weeks Results:High blood pressure decreased significantly after administration of both doxazosin and terazosin in double blind trial In open group,the result was similar The total response rate was 91 66% for treatment group,94 85% for control group and 90 00% for open group Doxazosin produced a favorable effect on serum lipid There were no significant changes in the liver and renal functions and electrocardiogram The incidence of adverse effects,such as dizziness,palpitation,was 14 50% for doxazosin group No significant difference between doxazosin and terazosin groups was found Conclusion:Doxazosin has a stable anti hypertensive effectiveness and a favorable effect on serum lipid The patients have a goos compliance

关 键 词：甲磺酸 多沙唑嗪 治疗 原发性高血压 临床研究 

分 类 号：R544.1[医药卫生—心血管疾病] R969[医药卫生—内科学]