慢性乙型肝炎患者血清TNF-α、IL-6、IL-8对肝纤维化及肝功能的影响  

Effect of serum TNF - α, IL - 6 and BL - 8 on liver flbrosis and liver function in patients with chronic hepatits B

作　　者：孙永年[1] 龚守军[1] 徐斌[1] 黄祝青[1] 

机构地区：[1]武警上海总队医院传染科,上海201103

出　　处：《武警医学》2002年第12期716-719,共4页Medical Journal of the Chinese People's Armed Police Force

摘　　要：目的 探讨慢性乙肝患者血清肿瘤坏死因子(Tumor necrosis factor-α,TNF-α)、白细胞介素-6(Interleukine-6,IL-6)、白细胞介素-8(Nterleukine-8,IL-8)的临床价值。方法 对146例乙肝患者采用ELISA法测定血清TNF-α、IL-6、IL-8的水平;同时对其血清透明质酸(Hyaline acid,HA)、Ⅲ型前胶原(Type Ⅲ procollagen,PC Ⅲ)、Ⅳ型胶原(Type Ⅳ collagen,C-Ⅳ)水平亦进行同步测定;并对68例行肝穿刺。结果 慢性乙型肝炎轻度、中度、重度及肝硬化患者血清TNF-α、IL-6、IL-8水平均不同程度高于对照组(P<0.01),随着肝损害程度的加重逐渐升高;并与肝损害程度及肝纤维化(HA、PCⅢ、C-Ⅳ)水平呈正相关关系(P<0.01)。血清TNF-α、IL-6、IL-8水平同血清胆红素(Total bilirubin)、谷丙转氨酶(ALT)亦呈正相关。结论 慢性乙型肝炎患者血清TNF-α、IL-6、IL-8水平与肝纤维化程度及肝功能损害发生发展密切相关;并能反映肝脏疾病的严重程度。Objective To investigate the clinical value of serum tumor necrosis factor-α(TNF-α), interleukin-6(IL-6) and interleukin-8 levels in patients with chronic hepatitis B. Methods Serum TNF-α, IL-6,IL-8, hyaline acid (HA), procollagen type Ⅲ (PC Ⅲ ), collagen type Ⅳ (C- Ⅳ ) levels were assayed in 146 patients by enzyme-linked immunosorbent assay of whom 68 underwent liver biopsy. Results Serum TNF-α,IL-6,and-8 levels in patients with chronic mild,moderate,and severe hepatitis,and hepatic cirrhosis were significantly higher than those in normal control group( P < 0.01) , and increased with increasing severity of chronic hepatitis B. They were positively correlated ( P < 0.01) with severity of liver damage and hepatic fibrosis,and also positively correlated with serum levels of total bilirubin and glutamic pyruvic tram-saminase. Conclusions Serum TNF-α,IL-6,and IL-8 levels in patients with chronic hepatitis B correlate closely with liver fibrosis and liver damage reflecting the severity of liver diseases.

关 键 词：TNF-α IL-6 IL-8 慢性乙型肝炎 白介素-6 白介素-8 肝纤维化 肝功能 肿瘤坏死因子-α ELISA法 

分 类 号：R512.62[医药卫生—内科学] R575[医药卫生—临床医学]