兔颞骨内面神经缺损人工室修复的功能性研究  

Functional test of regenerating rabbit intratemporal facial nerve in man-made chamber

作　　者：蔡萍[1] 刘公汉[1] 华清泉[1] 吴展元[1] 肖伯奎[1] 

机构地区：[1]武汉大学人民医院耳鼻咽喉头颈外科,430060

出　　处：《中华物理医学与康复杂志》2002年第1期21-23,共3页Chinese Journal of Physical Medicine and Rehabilitation

基　　金：湖北省教育委员会青年基金资助课题 (No.96B0 6 )

摘　　要：目的　通过测试再生神经及肌肉的功能 ,探讨神经再支配情况。方法　选用 48只成年大耳白兔 ,横断左侧颞骨内面神经 ,神经近端和远端分别用几丁质管和硅胶管桥接 ,术后 1个月、3个月和 5个月进行面部行为学观察以及电生理检查。结果　两种人工室 5个月组比 3个月组睑裂缩小 ,上唇自发运动有力 ,叩鼻后长须更明显偏向外侧 ,电极刺激神经后面肌收缩剧烈。神经电生理显示随着修复时间的延长 ,潜伏期逐渐缩短 ,动作电位波幅逐渐增高 ,神经 肌肉传导速度逐渐增快 ,两种人工室之间差异无显著性。结论　人工室修复颞骨内面神经缺损神经肌肉功能恢复良好 。ObjectiveTo investigate the reinnervation by testing the function of regenerating intratemporal facial nerve and muscles. Methods In 48 adult white rabbits, an unilateral 6 mm of intratemporal facial nerve gap was created for each rabbit, and then the proximal and distal stumps were inserted into chitin tube and silicone tube, respectively. After one, three, and five months, facial behavioral and electrophysiological tests were performed. Results The facial behavior indices including size of palpebral fissure, autonomous upper lip movement, whisker deviation following a midline nasal tap, and the quadratus labii superioris muscle contraction following intratemporal facial nerve stimulation in the rabbits after five months were all better than that observed during the proceding three months. Electrophysiological studies demonstrated that with the progress of regeneration the latency became shortened, the amplitude of action potential was increased, and the nerve muscle conduction velocity was increased. There was no significant difference between the two kinds of chambers. Conclusion Functional recovery of regenerating nerve and muscle could be accelerated by using the two different kinds of man made chambers.

关 键 词：颞骨内面神经缺损 修复 神经再生 人工室 功能测试 神经再支配 动物实验 

分 类 号：R762[医药卫生—耳鼻咽喉科]