选择素在家兔糖尿病酮症酸中毒肺损伤中的作用  

Role of selectin in lung injury in rabbits with diabetic ketoacidosis

作　　者：顾小军[1] 常家宝[1] 朱晓云[1] 殷国庆[1] 

机构地区：[1]东南大学医学院附属南京市第二医院内科,江苏南京210003

出　　处：《中国病理生理杂志》2002年第12期1506-1508,T001,共4页Chinese Journal of Pathophysiology

基　　金：东南大学资助项目 (No .XY - 0 0 2 6 - 0 61 )

摘　　要：目的 :研究选择素在糖尿病酮症酸中毒肺损伤中的作用。方法 :雄性新西兰家兔 1 2只 ,随机分为实验组 (DK组 ) 6只和生理盐水对照组 (NS组 ) 6只 ,DK组给予四氧嘧啶 (alloxan ) 1 50mg·kg- 1 和链脲佐菌素 (STZ ) 1 50mg·kg- 1 ,对照组给予等剂量生理盐水 ,72h后处死动物 ,检测动脉血气 ,取肺组织进行组化研究。结果 :实验组动物免疫组化显示选择素的表达增多。结论AIM: To study the effect of selectin on lung injury in rabbits with diabetic ketoacidosis(DKA). METHODS: 12 male New Zealand rabbits were divided into experimental group (DK groups, intravenous injection of streptozocin and alloxan monohydroate, n =6) and normal control group (received same dose of saline, n =6). After 72 hours, all the animals were killed and blood and lung tissue were collected. Blood gases, expressions of selectin-P and selectin-L were detected. RESULTS: The expression of selectin in DK group were higher than that in NS group. CONCLUSION: These results indicate that selectin expression may play an important role in lung injury during diabetic ketoacidosis.

关 键 词：糖尿病酮症酸中毒 肺 P选择素 L选择素 兔 

分 类 号：R587.1[医药卫生—内分泌]