四氢小檗碱的拆分  

Resolution of Tetrahydroberberine

作　　者：林云[1] 张灿[1] 华维一[1] 

机构地区：[1]中国药科大学新药研究中心,南京210009

出　　处：《中国药科大学学报》2002年第6期470-472,共3页Journal of China Pharmaceutical University

摘　　要：目的　通过化学拆分得到四氢小檗碱的光学异构体。方法　四氢小檗碱由小檗碱制备 ,以 ( - ) / ( + )二对甲苯甲酰酒石酸为拆分剂对其进行拆分。结果　拆分所得的 ( - ) / ( + )四氢小檗碱旋光值与文献报道一致。结论　通过化学拆分成功地获得了 ( - ) / ( + )AIM The purpose is to resolute tetrahydroberberine.METHODS Tetrahydroberberine was synthesized from berberine chloride,then resoluted with (+) /(-) di - o,o,-p -toluyl-tartaric acid which was prepared from D/L -tartaric acid.RESULTS AND CONCLUTION S (-)/ R (+)tetrahydroberberine was successfully obtained and the rotation degree was consistent with that reported.

关 键 词：四氢小檗碱 二对甲苯甲酰酒石酸 拆分 手性药物 

分 类 号：R917[医药卫生—药物分析学]