孕期沙眼衣原体、支原体感染结局及母婴传播  

The Result of Chlamydia Trachomatis and Mycoplasmal Infection and Transmission from Mother to Infant During Pregnancy.

作　　者：霍秀勤[1] 端青[2] 肖征[3] 李立安[1] 葛静[1] 翁霞云[1] 

机构地区：[1]解放军301医院妇产科,副主任医师100853 [2]解放军军事医学科学院微生物研究所 [3]解放军301医院微生物科

出　　处：《中国计划生育学杂志》2002年第12期746-748,共3页Chinese Journal of Family Planning

基　　金："军队优生优育专项基金"资助

摘　　要：目的:探讨孕期沙眼衣原体、支原体感染的妊娠结局和母婴传播途径。方法:采用沙眼衣原体、支原体属单克隆抗体免疫荧光法检测孕妇感染情况,观察孕期单项感染、混合感染及未感染者产时并发症、早产及胎儿异常,新生儿等情况。并在产时对孕期感染者的羊水、胎膜、胎盘、脐血、新生儿、死婴,应用McCoy传代细胞法和双相一步法,进行沙眼衣原体、解脲脲原体细胞培养,并将胎盘进行病理检测。结果:孕期感染与早破水、胎儿窘迫、胎盘残留、新生儿窒息无关;衣原体感染与胎膜残留有关(P<0.05);混合感染增加了胎儿异常、产后出血率(P<0.005);单项感染和混合感染均增加胎儿异常、早产、IUCR发生率(P<0.01)。细胞培养于胎盘、胎膜、脐血、羊水及死胎、活婴口腔、体液中找到衣原体和解脲脲原体。通过病理检测证实感染可造成胎盘功能不全。结论:孕期沙眼衣原体、支原体感染,可致病原菌上行,不同程度地感染胎盘、脐血、胎膜,污染羊水,致胎儿不良后果。Objective:To study the result of Chlamydia trachomatis and Mycoplasmal infection during pregnancy and the route of transmission from mother to infant. Methods; Chlamydia trachomatis and Mycoplasma monoclonal antibody immunofluores-cence is used to detect the infection of pregnant women. The complication during laler,peremature labor,fetal abnormality andneonates were observed among monoinfection, poyinfection and noninfection pregnancies respectively. During labor Me Coy and diphasic one step method are used to culture chlamydia trachomatis and M urealyticum cells of the infected women's amniotic fluid, fetal membranes, placentas, cord blood,neonates and dead infants,and pathologically examine placentas. Results: Infection during pregnancy is not caused by premature rupture of membranes, fetal distress, placental remnants , asphyxia neonatorum, etc; chlamydial infection is in relation to remnants of fetal membrances ( P < 0. 05 ) ; polyinfection increases the rate of fetal abnormality and the rate of bleeding after labor ( P < 0. 005 ) ; both monoinfection and polyinfection increase the rate of fetal abnormality, premature labor and the incidence of IUGR ( P < 0. 01) . Chlamydia and M. urealyticum are found in the cells cultivated in placentas,fetal membranes,cord blood,anniotic fluid,mouths and body fluid of dead fetuses and living infants. It's verified by pathologically examination that infection can cause placental incompetence. Conclusion: During pregnancy chlamydia trachomatis and mycoplasmal infection can cause athogenic bacteria to ascend and infect placenta, cord blood,fetal membranes and amniotic fluid to a certain degree,which can cause a harmful effect on fetus.

关 键 词：孕期 沙眼衣原体 支原体 感染 母婴传播 荧光抗体技术 细胞培养 妊娠结局 

分 类 号：R715[医药卫生—妇产科学]