妊高征孕妇血管紧张素转换酶基因的缺失多态性研究  

Study of deletion polymorphism of angiotensin converting enzyme locus in patients with pregnancy induced hypertension

作　　者：高秀艳[1] 丘晓红 叶飞[1] 陈立春[1] 邢丽华[1] 张为远[3] 

机构地区：[1]黑龙江省大庆油田总医院妇产科,163001 [2]黑龙江省哈尔滨红十字中心医院 [3]吉林大学第二临床医院妇产科

出　　处：《中国妇幼保健》2002年第12期738-740,共3页Maternal and Child Health Care of China

摘　　要：为了探讨血管紧张素转换酶 ( ACE)基因的缺失多态性与妊高征 ( PIH)的关系 ,检测妊高征孕妇 110例和对照组孕妇 81例 ,抽提她们外周静脉血白细胞中人类 DNA,用 PCR方法检测 ACE基因第 16内含子的 I/ D多态性。结果 :两组孕妇 ACE各基因型构成比及 I、D等位基因出现频率无显著差异 ( P>0 .0 5 )。提示 :ACE基因的缺失多态性及 I、 D等位基因与To study the relationship between deletion polymorphism of angiotensin converting enzyme locus(ACE)and pregnancy induced hypertension (PIH),110 patients of PIH and 81 cases of control group were detected by PCR, which detected I/D polymorphism of 16th introne on ACE gene .The results had showed that constituent ratio of ACE each gene type and frequency of ID allelotype between PIH and control group was not significant difference ( P >0.05). It indicated that deletion polymorphism of ACE gene and I, D allelotype were not related with PIH cause of disease.

关 键 词：妊高征 孕妇 血管紧张素转换酶基因 基因多态性 妊娠高血压综合征 基因缺失 

分 类 号：R714.246[医药卫生—妇产科学]