慢性阻塞性肺疾病合并阻塞性睡眠呼吸暂停低通气综合征患者血清维生素D水平的研究  

Observation of vitamin D levels in the patients with chronic obstructive pulmonary disease and obstructive sleep apnea hypopnea syndrome

作　　者：杨海华[1] 龙丰[1] 朱柠[1] 张霞 李善群 

机构地区：[1]复旦大学附属华山医院北院呼吸科,上海201907 [2]复旦大学附属中山医院呼吸科,上海200032 [3]复旦大学呼吸病研究所,上海200032

出　　处：《世界临床药物》2015年第6期384-387,共4页World Clinical Drug

基　　金：上海市卫生和计划生育委员会青年科研项目(20134Y003)

摘　　要：目的观察慢性阻塞性肺疾病(COPD)合并阻塞性睡眠呼吸暂停低通气综合征(OSAHS)(简称重叠综合征,OS)患者维生素D水平,并探讨维生素D缺乏对OS患者的影响。方法收集健康对照者和OS患者各36例,采集临床资料并进行多导睡眠图(PSG)监测。用酶联免疫吸附法(ELISA)测定血清中的25-羟维生素D[25-(OH)D]水平;将OS患者的体质量指数(BMI)、呼吸暂停低通气指数(AHI)、夜间最低血氧饱和度(LSa O2)、FEV1%和25-(OH)D水平作相关分析。结果 OS患者的血清中25-(OH)D水平明显低于健康对照者(P<0.05)。OS患者的25-(OH)D水平与患者BMI、AHI呈负相关(P<0.05);与患者FEV1%和LSa O2呈正相关(P<0.05)。结论维生素D缺乏在OS患者中患病率高,且维生素缺乏与OS患者的BMI、AHI、LSa O2和FEV1%相关。Objective To observe the vitamin D levels in the patients with chronic obstructive pulmonary disease(COPD)and obstructive sleep apnea hypopnea syndrome(OSAHS)(overlap syndrome, OS), and to explore the effect of vitamin D deficiency on the OS patients. Methods Thirty-six healthy subjects and thirty-six OS patients were enrolled in our study. The clinical and polysomnography data of healthy subjects and OS patients were collected, the serum levels of 25-(OH) D were measured by ELISA. The body mass index(BMI), the apnea hypopnea index(AHI), the lowest oxygen saturation(LSaO2)、the FEV1% and the levels of 25-(OH) D in OS patients were used for correlation analysis. Results The levels of 25-(OH)D were significantly lower in the OS patients than that in the healthy controls(P< 0.05). 25-(OH)D levels were negatively correlated with BMI and AHI(P< 0.05), and positively correlated with LSaO2 and FEV1%(P< 0.05). Conclusion Vitamin D deficiency is highly prevalent in OS patients, which correlated with BMI, AHI, FEV1% and LSaO2 in OS patients.

关 键 词：慢性阻塞性肺疾病(COPD) 阻塞性睡眠呼吸暂停低通气综合征(OSAHS) 重叠综合征(OS) 维生 

分 类 号：R563.9[医药卫生—呼吸系统] R766[医药卫生—内科学]