拉呋替丁刺激辣椒素敏感传入神经介导的消化道黏膜保护的研究进展  

Protective effect of lafutidine on gastrointestinal mucosa mediated by capsaicin-sensitive afferent neurons

作　　者：金玉[1] 周海波[2] 曾繁典[3] 谭诗云[4] 

机构地区：[1]武昌理工学院生命科学学院,武汉430223 [2]武汉大学医学部,武汉430071 [3]华中科技大学同济医学院药理学系,武汉430030 [4]武汉大学人民医院消化科,武汉430060

出　　处：《世界临床药物》2015年第6期432-436,共5页World Clinical Drug

摘　　要：辣椒素敏感传入神经(CSAN)在维持胃黏膜屏障的完整性方面具有重要作用。拉呋替丁为具有抑制胃酸分泌和保护消化道黏膜作用的H2受体阻滞剂,可激活CSAN,介导降钙素基因相关肽、一氧化氮释放增加,从而抑制胃酸分泌,增加胃黏膜血流量,促进黏膜上皮再生,促进黏液分泌,进而发挥保护消化道黏膜,抵御各种攻击性因素如盐酸、酒精、胆汁、非甾体消炎药和化疗药等对黏膜的损伤。本文着重描述CSAN介导的黏膜保护作用及拉呋替丁通过刺激CSAN保护消化道黏膜的作用机制及疗效。Capsaicin sensitive afferent neurons(CSANs) play a crucial role in maintaining the integrity of gastrointestinal mucosa. As a novel H2 RA with anti-secretory effect and mucosa-protective action, lafutidine may activate CSANs, promote the synthesis and release of CGRP and NO, further control gastric acid secretion, increase gastric mucosal blood flow and promote epithelial regeneration and mucus secretion. It can provide gastrointestinal mucosa protection against various nociceptive factors such as hydrochloric acid, alcohol, bile, non-steroidal anti-inflammatory drugs, and chemotherapy drugs. This review focuses on lafutidine and its mucosal protective effect mediated by CSANs.

关 键 词：拉呋替丁 辣椒素敏感传入神经 降钙素基因相关肽 一氧化氮 消化道黏膜保护 

分 类 号：R96[医药卫生—药理学]