Dam1复合体在动粒-微管互作中的作用  

Functions of Dam1 Complex in Outer Kinetochore

作　　者：胡逸超 许雨晨 鹿宗贵 陈保善[2] 彭好文[1,2] 

机构地区：[1]广西大学农学院,南宁530001 [2]广西大学亚热带农业生物资源保护与利用国家重点实验室,南宁530001

出　　处：《基因组学与应用生物学》2015年第4期896-901,共6页Genomics and Applied Biology

基　　金：国家自然科学基金(31160356);广西自然科学基金(2014GXNSFAA118101)共同资助

摘　　要：细胞有丝分裂时动粒和纺锤体之间的相互作用对保证染色体分离的准确性至关重要,错误连接在前中期或中期时需要被修正。染色体要保持正确的连接直到后期纺锤丝将它们拉向两极。在对S.cerevisiae和S.pombe的研究中,非马达微管蛋白Dam1复合体对保持这样的连接起到了重要作用。本文主要介绍了有关Dam1复合体功能的一些关键性试验并且讨论了在酵母和其它有机体中它对于动粒-微管连接的意义。The adjustion of the interaction between the kinetochores and mitotic spindle is important to ensure the accuracy of the chromosome segregation; the fault attachments would be amended at premetaphase and metaphase.The attachments of chromosome to spindle fibers have to be correct during the traction to opposite poles of cell.The non-motor protein Dam1 complex is vital to maintain this attachment in yeast. In S. cerevisiae and S. pombe,the Dam1 complex, which locate at the kinetochore, play a role of maintaining correct attachment between spindles and chromosome. In this article, some key functional experiments of Dam1 complex and the implication of kinetochore-microtubules attachments in yeast and other organisms have been reviewed.

关 键 词：Dam1复合体 动粒 微管 纺锤体 

分 类 号：Q343[生物学—遗传学]