全小肠切除大鼠结肠代偿性增生  

Morphologic colonic adaptation following total small bowel resection in the rat

作　　者：吴文川[1] 靳大勇[1] 张焱焱[2] 

机构地区：[1]复旦大学附属中山医院普外科,上海200032 [2]华北煤炭医学院附属医院普外科,河北唐山063000

出　　处：《肠外与肠内营养》2002年第4期230-231,234,共3页Parenteral & Enteral Nutrition

摘　　要：目的 :旨在研究全小肠切除术后大鼠结肠代偿的形态学改变。　方法 :随机取正常大鼠为对照组 (n =10 ) ,全小肠切除术后经肠内营养 (EN)支持存活 3个月以上的大鼠为实验组 (n =10 ) ,然后切取结肠进行形态学研究。　结果 :实验组结肠长度、直径、湿重、腺窝深度、皱襞高度及粘膜厚度均优于对照组 ,差异非常显著 (P <0 .0 1)。　结论 :大鼠全小肠切除术后经过肠内营养支持 ,结肠发生了极为明显的适应性代偿增生。Objectives:To investigate the morphologic changes of the colon in the rats after a total small bowel resection. Methods:Ten male Sprague Dawley(350～370 g) rats in the experimental group were undergone resection of total small bowel,and ten normal rats were randomly chosen as the control group.After supported by enteral nutrition for 3 months,rats were sacrificed and the colon harvested for morphologic parameters study. Results:The length,diameter,wet weight,crypt depth,mucosal thickness and kerckring height of the colon in the experimental group were significantly higher than those in the control group( P <0.01). Conclusions:After a total small bowel resection and enteral nutrition support,the morphologic compensatory adaptation occurred significantly in the colon.

关 键 词：结肠代偿性增生 全小肠切除 肠内营养 大鼠 

分 类 号：R656.7[医药卫生—外科学]