微波消解/ICP-MS法测定人体肺及肾脏中稀土元素  

Determination of Rare Earth Elements in Human Lung and Kidney at Ultratrace Levels by Microwave Dissolution and Inductively Coupled Plasma-MS Spectrometry

作　　者：谢建滨[1] 刘桂华[1] 柳其芳[1] 刘小立[1] 李筱薇[2] 高俊全[2] 

机构地区：[1]深圳市卫生防疫站,518020 [2]中国预防医学科学院食品营养与卫生研究所

出　　处：《中国公共卫生》2002年第12期1502-1504,共3页Chinese Journal of Public Health

基　　金：国家自然科学基金资助 (39570 2 34);国际原子能机构协作研究基金资助 (891 8/RI)

摘　　要：目的　建立人体器官组织肺及肾脏中超微量稀土元素的测定方法。方法　样品经HNO3 +H2 O2 微波消解体系消解后 ,以铑作为内标 ,直接用电感耦合等离子体质谱法 (ICP -MS)测定人体肺及肾脏中超微量稀土元素镧、铈、镤、钕、钐、铕、钆、铽、镝、钬、铒、铥、镱、镥。结果　 14个稀土元素的检出限分别在 0 8ng/L～ 4ng/L之间 ;线性良好 ,可达 3个数量级以上 ,线性相关系数均≥ 0 997;精密度良好RSD <3% ;回收率在 98%～ 113%之间 ,对人发标准物质GBW0 76 0 1及小麦粉标准物质GBW 0 85 0 3测定 ,结果满意。结论　ICP -MS法是测定人体肺及肾脏组织中超微量稀土元素有效的分析方法 ,内标元素铑可补偿基体效应 ,质谱干扰可用干扰校正系数校正。ObjectiveTo establish the method for the determination of rare earth elements at ultratrace levels in human organs.MethodsThe samples were digested by closed-vessel microwave HNO 3+H 2O 2 dissolution system.The solution was directly analyzed by ICP-MS for the determination of La Ce Pr Nd Sm Eu Gd Tb Dy Ho Er Tm Yb Lu in human lung and kidney with rhenium internal calibration.ResultsThe method provided excellent sensitivity and accuracy.It was efficiency for the determinatin of fourteen REEs.The detection limits were range from 0.8ng/L to 4ng/L depending on the elements.Linear calibration plots exhibited over three orders of magnitude with standard linear correlation r≥0.997.Recoveries of spiked samples were of the range 98%-113% and precision was fine RSD>3%.The results showed close agreement with the reference values in two standard reference materials of human hair GBW07601 and wheat flour GBW08503.ConclusionICP-MS was an effective method to analyse rare earth elements of lung and kidney.Using Rh as an internal standard compensated the depression of signal.The problem of the molecular overlaps was corrected by the interference correction factor.

关 键 词：微波消解 ICP-MS 肺 肾脏 稀土元素 

分 类 号：R194[医药卫生—卫生事业管理]