高压氧对脊髓损伤大鼠脊髓组织内源性阿片肽含量的影响  

EFFECT OF HYPERBARIC OXYGEN ON CONCENTRATION OF ENDOGENOUS OPIATE PEPTIDE IN SPINAL CORD TISSUES OF SPINAL CORD INJURY

作　　者：方健 侯铁胜[2] 姜波[2] 方以群[3] 胥军民[4] 陈文笔[1] 傅强[2] 刘景昌[3] 

机构地区：[1]解放军第105医院 [2]第二军医大学长海医院 [3]上海海军医学研究所 [4]第二军医大学基础部

出　　处：《解放军医学杂志》2002年第12期1088-1090,共3页Medical Journal of Chinese People's Liberation Army

基　　金：全军医学重点实验室基金资助课题(编号 0 37)

摘　　要：为探讨高压氧 (HBO)治疗脊髓损伤 (SCI)的机制 ,复制SCI模型 ,观察HBO对SCI大鼠脊髓组织中内源性阿片肽 (β EP及DynA)含量的影响。结果显示 ,损伤后大鼠脊髓组织中DynA和β EP含量均明显升高 ;0 2 5MPaHBO治疗后DynA及 β EP含量均下降 ,以DynA为著。提示内源性阿片肽参与了SCI的继发性损伤机制 ,且以DynA的作用为主 ;HBO可抑制SCI后内源性阿片肽的释放 。To study the mechanism of hyperbaric oxygen (HBO) on spinal cord injury (SCI), we duplicated a rat SCI model and observed the influence of HBO on concentration of endogenous opiate peptides (including Dyn A and β EP) in spinal cord tissues. The results showed that the concentrations of Dyn A and β EP in the spinal cord all significantly increased after injury. And they all decreased after treated with 0 25 MPa HBO, with the concentration of Dyn A changed more significantly. These results suggest that endogenous opiate peptide takes part in the secondary injury of SCI and mainly with Dyn A. HBO can inhibit the release of endogenous opiate peptide after SCI and thus recover the function of spinal cord tissues.

关 键 词：高压氧 脊髓损伤 大鼠 脊髓组织 内源性阿片肽 继发性损伤 

分 类 号：R651.2[医药卫生—外科学] R459.[医药卫生—临床医学]