米索前列醇在足月妊娠引产中阴道给药方法观察  

Approaches to administrations of misoprostol in induced labor for full term pregnancy

作　　者：周玉玲[1] 王雷[1] 郭小平[1] 王景芬[1] 贾艳君[1] 李靖[1] 

机构地区：[1]解放军252医院,河北保定071000

出　　处：《华北国防医药》2002年第6期387-389,共3页Medical Journal of Beijing Military Region

摘　　要：目的　探讨米索前列醇 (米索 )在足月妊娠引产中阴道给药的方法。　方法　符合试验条件的足月妊娠产妇10 6例作为研究对象 ,随机分为A、B两组 ,分别以米索 5 0 μg、2 5 μg放置于阴道后穹隆 ,每 3小时 1次 ,直至临产停药 ,1日用药以 4次为限。选择同期住院 ,自然临产的初产妇 5 6例为C组作为对照。　结果　①两试验组间 ,B组用药次数明显多于A组 ,差异非常显著 (P <0 0 1) ,用药至临产时间、引产时间B组长于A组 ,差异显著 (P <0 0 5 ) ,而两组引产成功率无明显差异。②与对照组比较 ,3组分娩方式、新生儿体重、羊水粪染及胎儿窘迫发生率及新生儿出生后评分均无显著差异 (P>0 0 5 )。经阴道分娩者 ,出现继发性宫缩乏力的比率 ,B组明显高于A组 ,且B组第一产程、总产程时间明显长于A组而与对照组相近 ,差异显著 (P <0 0 5 )。　结论　在足月妊娠引产中 ,以 5 0 μg米索每 3小时阴道放置一次较为安全有效 ,但要注意个体差异 ,须严格掌握指征 。Objective To explore the acceptable vaginal administration methods of misoprostol in induced labor for full term pregnancy. Methods 106 primiparas at term pregnancy with inclusion criteria were divided randomly into two groups.56 subjects in group A and 50 subjects in Group B respectly received the misoprostol 50 μg,25 μg vaginally every 3 hours;all subjects received the drug constantly until the onset of labor.The highest frequency was 4 times per day.56 cases of hospitalized normal labor in same period were treated as control group. Results ①Between the two study groups,the administration of the drug in group A was much more frequent than that in group B with a statistically significant difference ( P <0.01).The interval between the first administration and the onset of labor,and induction time in group B were both significantly longer than those in group A ( P <0.05) .While there were no statistical difference in the success rate of labor induction between the two groups.②Compared with the control group,there were no statistical differences in the way of parturition,the neonatal weight,the incidence of amniotic fluid contaminated with meconium,fetal distress and the neonatal Apgar score among the three groups ( P >0.05).For vaginal delivery,the incidence of secondary inefficient contraction in group B was greatly higher than that in group A,the first stage and total labor in group B took significantly longer time than that in group A,but they took the same time as those in the control group( P<0.05 ). Conclusions Vaginal administration of misoprostol 50 μg every three hours was effective and secure in induced labor for full term pregnancy.However, individual difference needed to be notified and the indications must strictly be followed.

关 键 词：米索前列醇 足月妊娠 阴道给药 剂量效应关系 药物引产 

分 类 号：R719.21[医药卫生—妇产科学]